Repository logo
 

Myosin II Controls Junction Fluctuations to Guide Epithelial Tissue Ordering.

Simple item page
cam.issuedOnline2017-10-26
dc.contributor.authorCurran, Scott
dc.contributor.authorStrandkvist, Charlotte
dc.contributor.authorBathmann, Jasper
dc.contributor.authorde Gennes, Marc
dc.contributor.authorKabla, Alexandre
dc.contributor.authorSalbreux, Guillaume
dc.contributor.authorBaum, Buzz
dc.contributor.orcidKabla, Alexandre [0000-0002-0280-3531]
dc.date.accessioned2018-11-24T00:31:01Z
dc.date.available2018-11-24T00:31:01Z
dc.date.issued2017-11-20
dc.description.abstractUnder conditions of homeostasis, dynamic changes in the length of individual adherens junctions (AJs) provide epithelia with the fluidity required to maintain tissue integrity in the face of intrinsic and extrinsic forces. While the contribution of AJ remodeling to developmental morphogenesis has been intensively studied, less is known about AJ dynamics in other circumstances. Here, we study AJ dynamics in an epithelium that undergoes a gradual increase in packing order, without concomitant large-scale changes in tissue size or shape. We find that neighbor exchange events are driven by stochastic fluctuations in junction length, regulated in part by junctional actomyosin. In this context, the developmental increase of isotropic junctional actomyosin reduces the rate of neighbor exchange, contributing to tissue order. We propose a model in which the local variance in tension between junctions determines whether actomyosin-based forces will inhibit or drive the topological transitions that either refine or deform a tissue.
dc.format.mediumPrint-Electronic
dc.identifier.doi10.17863/CAM.33258
dc.identifier.eissn1878-1551
dc.identifier.issn1534-5807
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/285931
dc.languageeng
dc.language.isoeng
dc.publisherElsevier BV
dc.publisher.urlhttp://dx.doi.org/10.1016/j.devcel.2017.09.018
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectDrosophila
dc.subjectMyosin
dc.subjectcadherin
dc.subjectepithelia
dc.subjectjunction fluctuations
dc.subjectmorphogenesis
dc.subjectneighbor exchange
dc.subjecttissue mechanics
dc.subjecttissue refinement
dc.subjectvertex model
dc.subjectActomyosin
dc.subjectAdherens Junctions
dc.subjectAnimals
dc.subjectCadherins
dc.subjectDrosophila Proteins
dc.subjectDrosophila melanogaster
dc.subjectEpithelium
dc.subjectMyosin Type II
dc.titleMyosin II Controls Junction Fluctuations to Guide Epithelial Tissue Ordering.
dc.typeArticle
dcterms.dateAccepted2017-09-22
prism.endingPage492.e6
prism.issueIdentifier4
prism.publicationDate2017
prism.publicationNameDev Cell
prism.startingPage480
prism.volume43
rioxxterms.licenseref.startdate2017-11
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1016/j.devcel.2017.09.018

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Curran_Myosin_II_Controls_Junction_Full.pdf
Size:
14.55 MB
Format:
Adobe Portable Document Format
Description:
Published version
Licence
https://creativecommons.org/licenses/by/4.0/
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
DepositLicenceAgreementv2.1.pdf
Size:
150.9 KB
Format:
Adobe Portable Document Format
Download

Collections

Cambridge University Research Outputs