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A SoxB gene acts as an anterior gap gene and regulates posterior segment addition in a spider.

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cam.issuedOnline2018-08-21
dc.contributor.authorPaese, Christian Louis Bonatto
dc.contributor.authorSchoenauer, Anna
dc.contributor.authorLeite, Daniel J
dc.contributor.authorRussell, Steven
dc.contributor.authorMcGregor, Alistair P
dc.contributor.orcidPaese, Christian Louis Bonatto [0000-0001-5992-5209]
dc.contributor.orcidRussell, Steven [0000-0003-0546-3031]
dc.contributor.orcidMcGregor, Alistair P [0000-0002-2908-2420]
dc.date.accessioned2018-10-03T04:45:30Z
dc.date.available2018-10-03T04:45:30Z
dc.date.issued2018-08-21
dc.description.abstractSox genes encode a set of highly conserved transcription factors that regulate many developmental processes. In insects, the SoxB gene Dichaete is the only Sox gene known to be involved in segmentation. To determine if similar mechanisms are used in other arthropods, we investigated the role of Sox genes during segmentation in the spider Parasteatoda tepidariorum. While Dichaete does not appear to be involved in spider segmentation, we found that the closely related Sox21b-1 gene acts as a gap gene during formation of anterior segments and is also part of the segmentation clock for development of the segment addition zone and sequential addition of opisthosomal segments. Thus, we have found that two different mechanisms of segmentation in a non-mandibulate arthropod are regulated by a SoxB gene. Our work provides new insights into the function of an important and conserved gene family, and the evolution of the regulation of segmentation in arthropods.
dc.format.mediumElectronic
dc.identifier.doi10.17863/CAM.30457
dc.identifier.eissn2050-084X
dc.identifier.issn2050-084X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/283095
dc.languageeng
dc.language.isoeng
dc.publishereLife Sciences Publications, Ltd
dc.publisher.urlhttp://dx.doi.org/10.7554/elife.37567
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectdevelopment
dc.subjectdevelopmental biology
dc.subjectevolution
dc.subjectevolutionary biology
dc.subjectparasteatoda tepidariorum
dc.subjectsegmentation
dc.subjectspider
dc.subjectAnimals
dc.subjectBiological Evolution
dc.subjectBody Patterning
dc.subjectGene Expression Regulation, Developmental
dc.subjectSOXB2 Transcription Factors
dc.subjectSpiders
dc.titleA SoxB gene acts as an anterior gap gene and regulates posterior segment addition in a spider.
dc.typeArticle
dcterms.dateAccepted2018-08-10
prism.publicationDate2018
prism.publicationNameElife
prism.volume7
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/N007069/1)
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/L002817/1)
rioxxterms.licenseref.startdate2018-08-21
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review
rioxxterms.versionVoR
rioxxterms.versionofrecord10.7554/eLife.37567

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