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Cellular mechanisms of incretin hormone secretion.

Published version
Peer-reviewed

Repository DOI


Type

Article

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Authors

Santos-Hernández, Marta 
Gribble, Fiona M 

Abstract

Enteroendocrine cells located along the gastrointestinal epithelium sense different nutrients/luminal contents that trigger the secretion of a variety of gut hormones with different roles in glucose homeostasis and appetite regulation. The incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are involved in the regulation of insulin secretion, appetite, food intake and body weight after their nutrient-induced secretion from the gut. GLP-1 mimetics have been developed and used in the treatment of type 2 diabetes mellitus and obesity. Modulating the release of endogenous intestinal hormones may be a promising approach for the treatment of obesity and type 2 diabetes without surgery. For that reason, current understanding of the cellular mechanisms underlying intestinal hormone secretion will be the focus of this review. The mechanisms controlling hormone secretion depend on the nature of the stimulus, involving a variety of signalling pathways including ion channels, nutrient transporters and G-protein-coupled receptors.

Description

Keywords

GIP, GLP-1, diabetes, enteroendocrine cells, incretin, obesity, Humans, Incretins, Diabetes Mellitus, Type 2, Gastric Inhibitory Polypeptide, Glucagon-Like Peptide 1, Obesity, Glucose, Insulin

Journal Title

J Mol Endocrinol

Conference Name

Journal ISSN

0952-5041
1479-6813

Volume Title

72

Publisher

Bioscientifica
Sponsorship
Medical Research Council (MC_PC_12012)