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Computed tomography pericoronary adipose tissue density predicts coronary allograft vasculopathy and adverse clinical outcomes after cardiac transplantation.

Accepted version
Peer-reviewed

Type

Article

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Authors

Wall, Christopher 
Weir-McCall, Jonathan 
Tweed, Katharine 
Hoole, Stephen P 

Abstract

AIMS: To assess pericoronary adipose tissue (PCAT) density on coronary computed tomography angiography (CCTA) as a marker of inflammatory disease activity in coronary allograft vasculopathy (CAV). METHODS AND RESULTS: PCAT density, lesion volumes, and total vessel volume-to-myocardial mass ratio (V/M) were retrospectively measured in 126 CCTAs from 94 heart transplant patients [mean age 49 (SD 14.5) years, 40% female] who underwent imaging between 2010 and 2021; age- and sex-matched controls; and patients with atherosclerosis. PCAT density was higher in transplant patients with CAV [n = 40; -73.0 HU (SD 9.3)] than without CAV [n = 86; -77.9 HU (SD 8.2)], and controls [n = 12; -86.2 HU (SD 5.4)], P < 0.01 for both. Unlike patients with atherosclerotic coronary artery disease (n = 32), CAV lesions were predominantly non-calcified and comprised of mostly fibrous or fibrofatty tissue. V/M was lower in patients with CAV than without [32.4 mm3/g (SD 9.7) vs. 41.4 mm3/g (SD 12.3), P < 0.0001]. PCAT density and V/M improved the ability to predict CAV from area under the receiver operating characteristic curve (AUC) 0.75-0.85 when added to donor age and donor hypertension status (P < 0.0001). PCAT density above -66 HU was associated with a greater incidence of all-cause mortality {odds ratio [OR] 18.0 [95% confidence interval (CI) 3.25-99.6], P < 0.01} and the composite endpoint of death, CAV progression, acute rejection, and coronary revascularization [OR 7.47 (95% CI 1.8-31.6), P = 0.01] over 5.3 (SD 2.1) years. CONCLUSION: Heart transplant patients with CAV have higher PCAT density and lower V/M than those without. Increased PCAT density is associated with adverse clinical outcomes. These CCTA metrics could be useful for the diagnosis and monitoring of CAV severity.

Description

Keywords

coronary allograft vasculopathy, coronary computed tomography angiography, heart transplantation, pericoronary adipose tissue density, Humans, Female, Male, Middle Aged, Adipose Tissue, Heart Transplantation, Retrospective Studies, Coronary Artery Disease, Computed Tomography Angiography, Coronary Angiography, Adult, Predictive Value of Tests, Case-Control Studies, Allografts, Risk Assessment, Postoperative Complications, Epicardial Adipose Tissue

Journal Title

Eur Heart J Cardiovasc Imaging

Conference Name

Journal ISSN

2047-2404
2047-2412

Volume Title

Publisher

Oxford University Press (OUP)
Sponsorship
Wellcome Trust (211100/Z/18/Z)
British Heart Foundation (FS/CRTF/23/24445)
British Heart Foundation (RE/18/1/34212)
National Institute for Health and Care Research (IS-BRC-1215-20014)
British Heart Foundation (FS/CRTF/20/24035)