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Age-specific breast cancer risk by body mass index and familial risk: prospective family study cohort (ProF-SC).

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cam.issuedOnline2018-11-03
dc.contributor.authorHopper, John L
dc.contributor.authorDite, Gillian S
dc.contributor.authorMacInnis, Robert J
dc.contributor.authorLiao, Yuyan
dc.contributor.authorZeinomar, Nur
dc.contributor.authorKnight, Julia A
dc.contributor.authorSouthey, Melissa C
dc.contributor.authorMilne, Roger L
dc.contributor.authorChung, Wendy K
dc.contributor.authorGiles, Graham G
dc.contributor.authorGenkinger, Jeanine M
dc.contributor.authorMcLachlan, Sue-Anne
dc.contributor.authorFriedlander, Michael L
dc.contributor.authorAntoniou, Antonis C
dc.contributor.authorWeideman, Prue C
dc.contributor.authorGlendon, Gord
dc.contributor.authorNesci, Stephanie
dc.contributor.authorkConFab Investigators
dc.contributor.authorAndrulis, Irene L
dc.contributor.authorBuys, Saundra S
dc.contributor.authorDaly, Mary B
dc.contributor.authorJohn, Esther M
dc.contributor.authorPhillips, Kelly Anne
dc.contributor.authorTerry, Mary Beth
dc.contributor.orcidHopper, John L [0000-0002-8567-173X]
dc.date.accessioned2018-12-05T00:30:45Z
dc.date.available2018-12-05T00:30:45Z
dc.date.issued2018-11-03
dc.description.abstractBACKGROUND: The association between body mass index (BMI) and risk of breast cancer depends on time of life, but it is unknown whether this association depends on a woman's familial risk. METHODS: We conducted a prospective study of a cohort enriched for familial risk consisting of 16,035 women from 6701 families in the Breast Cancer Family Registry and the Kathleen Cunningham Foundation Consortium for Research into Familial Breast Cancer followed for up to 20 years (mean 10.5 years). There were 896 incident breast cancers (mean age at diagnosis 55.7 years). We used Cox regression to model BMI risk associations as a function of menopausal status, age, and underlying familial risk based on pedigree data using the Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA), all measured at baseline. RESULTS: The strength and direction of the BMI risk association depended on baseline menopausal status (P < 0.001); after adjusting for menopausal status, the association did not depend on age at baseline (P = 0.6). In terms of absolute risk, the negative association with BMI for premenopausal women has a much smaller influence than the positive association with BMI for postmenopausal women. Women at higher familial risk have a much larger difference in absolute risk depending on their BMI than women at lower familial risk. CONCLUSIONS: The greater a woman's familial risk, the greater the influence of BMI on her absolute postmenopausal breast cancer risk. Given that age-adjusted BMI is correlated across adulthood, maintaining a healthy weight throughout adult life is particularly important for women with a family history of breast cancer.
dc.format.mediumElectronic
dc.identifier.doi10.17863/CAM.33621
dc.identifier.eissn1465-542X
dc.identifier.issn1465-5411
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/286311
dc.languageeng
dc.language.isoeng
dc.publisherSpringer Science and Business Media LLC
dc.publisher.urlhttp://dx.doi.org/10.1186/s13058-018-1056-1
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectBody mass index
dc.subjectBreast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm
dc.subjectBreast cancer
dc.subjectFamilial risk
dc.subjectGene–environment interaction
dc.subjectAdult
dc.subjectAge Factors
dc.subjectAged
dc.subjectAustralia
dc.subjectBody Mass Index
dc.subjectBreast Neoplasms
dc.subjectCanada
dc.subjectFemale
dc.subjectFollow-Up Studies
dc.subjectHumans
dc.subjectIncidence
dc.subjectMedical History Taking
dc.subjectMiddle Aged
dc.subjectNew Zealand
dc.subjectPostmenopause
dc.subjectPremenopause
dc.subjectProspective Studies
dc.subjectRegistries
dc.subjectRisk Factors
dc.subjectUnited States
dc.subjectYoung Adult
dc.titleAge-specific breast cancer risk by body mass index and familial risk: prospective family study cohort (ProF-SC).
dc.typeArticle
dcterms.dateAccepted2018-10-02
prism.issueIdentifier1
prism.publicationDate2018
prism.publicationNameBreast Cancer Res
prism.startingPage132
prism.volume20
pubs.funder-project-idCancer Research UK (20861)
rioxxterms.licenseref.startdate2018-11-03
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1186/s13058-018-1056-1

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