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Mutation rate dynamics reflect ecological change in an emerging zoonotic pathogen.

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cam.issuedOnline2021-11-08
datacite.isderivedfrom.doi10.1101/2021.04.12.439332
dc.contributor.authorMurray, Gemma GR
dc.contributor.authorBalmer, Andrew J
dc.contributor.authorHerbert, Josephine
dc.contributor.authorHadijirin, Nazreen F
dc.contributor.authorKemp, Caroline L
dc.contributor.authorMatuszewska, Marta
dc.contributor.authorBruchmann, Sebastian
dc.contributor.authorHossain, AS Md Mukarram
dc.contributor.authorGottschalk, Marcelo
dc.contributor.authorTucker, Alexander W
dc.contributor.authorMiller, Eric
dc.contributor.authorWeinert, Lucy A
dc.contributor.orcidMurray, Gemma [0000-0002-9531-1711]
dc.contributor.orcidBalmer, Andrew [0000-0001-7446-3428]
dc.contributor.orcidMatuszewska, Marta [0000-0002-2653-7725]
dc.contributor.orcidBruchmann, Sebastian [0000-0001-8721-5386]
dc.contributor.orcidTucker, Alexander [0000-0003-0062-0843]
dc.contributor.orcidWeinert, Lucy [0000-0002-9279-6012]
dc.date.accessioned2022-01-07T11:11:51Z
dc.date.available2022-01-07T11:11:51Z
dc.date.issued2021-11
dc.date.updated2022-01-07T11:11:50Z
dc.descriptionFunder: Raymond and Beverly Sackler Foundation
dc.descriptionFunder: Isaac Newton Trust
dc.descriptionFunder: Newnham College, University of Cambridge
dc.descriptionFunder: Medical Research Council
dc.description.abstractMutation rates vary both within and between bacterial species, and understanding what drives this variation is essential for understanding the evolutionary dynamics of bacterial populations. In this study, we investigate two factors that are predicted to influence the mutation rate: ecology and genome size. We conducted mutation accumulation experiments on eight strains of the emerging zoonotic pathogen Streptococcus suis. Natural variation within this species allows us to compare tonsil carriage and invasive disease isolates, from both more and less pathogenic populations, with a wide range of genome sizes. We find that invasive disease isolates have repeatedly evolved mutation rates that are higher than those of closely related carriage isolates, regardless of variation in genome size. Independent of this variation in overall rate, we also observe a stronger bias towards G/C to A/T mutations in isolates from more pathogenic populations, whose genomes tend to be smaller and more AT-rich. Our results suggest that ecology is a stronger correlate of mutation rate than genome size over these timescales, and that transitions to invasive disease are consistently accompanied by rapid increases in mutation rate. These results shed light on the impact that ecology can have on the adaptive potential of bacterial pathogens.
dc.identifier.doi10.17863/CAM.79736
dc.identifier.eissn1553-7404
dc.identifier.issn1553-7390
dc.identifier.otherPMC8601623
dc.identifier.other34748531
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/332289
dc.languageeng
dc.language.isoeng
dc.publisherPublic Library of Science (PLoS)
dc.publisher.urlhttp://dx.doi.org/10.1371/journal.pgen.1009864
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceessn: 1553-7404
dc.sourcenlmid: 101239074
dc.subjectAdaptation, Biological
dc.subjectAnimals
dc.subjectCommunicable Diseases, Emerging
dc.subjectEcology
dc.subjectMutation Rate
dc.subjectStreptococcal Infections
dc.subjectStreptococcus suis
dc.subjectVirulence
dc.subjectZoonoses
dc.titleMutation rate dynamics reflect ecological change in an emerging zoonotic pathogen.
dc.typeArticle
dcterms.dateAccepted2021-10-06
prism.issueIdentifier11
prism.publicationNamePLoS Genetics
prism.volume17
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/L018934/1)
pubs.funder-project-idWellcome Trust (109385/Z/15/Z)
pubs.funder-project-idEuropean Commission Horizon 2020 (H2020) Societal Challenges (727966)
pubs.funder-project-idBBSRC (2113638)
pubs.funder-project-idMedical Research Council (1933099)
pubs.funder-project-idMRC (MR/V032836/1)
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1371/journal.pgen.1009864

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