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Short-term psychosocial outcomes of adding a non-contrast abdominal computed tomography (CT) scan to the thoracic CT within lung cancer screening.

Published version
Peer-reviewed

Repository DOI


Change log

Authors

Usher-Smith, Juliet A  ORCID logo  https://orcid.org/0000-0002-8501-2531
Godoy, Angela 
Kitt, Jessica 
Farquhar, Fiona 
Waller, Jo 

Abstract

OBJECTIVES: To evaluate psychological, social, and financial outcomes amongst individuals undergoing a non-contrast abdominal computed tomography (CT) scan to screen for kidney cancer and other abdominal malignancies alongside the thoracic CT within lung cancer screening. SUBJECTS AND METHODS: The Yorkshire Kidney Screening Trial (YKST) is a feasibility study of adding a non-contrast abdominal CT scan to the thoracic CT within lung cancer screening. A total of 500 participants within the YKST, comprising all who had an abnormal CT scan and a random sample of one-third of those with a normal scan between 14/03/2022 and 24/08/2022 were sent a questionnaire at 3 and 6 months. Outcomes included the Psychological Consequences Questionnaire (PCQ), the short-form of the Spielberger State-Trait Anxiety Inventory, and the EuroQoL five Dimensions five Levels scale (EQ-5D-5L). Data were analysed using regression adjusting for participant age, sex, socioeconomic status, education, baseline quality of life (EQ-5D-5L), and ethnicity. RESULTS: A total of 380 (76%) participants returned questionnaires at 3 months and 328 (66%) at 6 months. There was no difference in any outcomes between participants with a normal scan and those with abnormal scans requiring no further action. Individuals requiring initial further investigations or referral had higher scores on the negative PCQ than those with normal scans at 3 months (standardised mean difference 0.28 sd, 95% confidence interval 0.01-0.54; P = 0.044). The difference was greater in those with anxiety or depression at baseline. No differences were seen at 6 months. CONCLUSION: Screening for kidney cancer and other abdominal malignancies using abdominal CT alongside the thoracic CT within lung cancer screening is unlikely to cause significant lasting psychosocial or financial harm to participants with incidental findings.

Description

Publication status: Published


Funder: Cancer Research UK; doi: http://dx.doi.org/10.13039/501100000289


Funder: National Institute for Health and Care Research


Funder: NIHR Cambridge Biomedical Research Centre


Funder: Yorkshire Cancer Research; doi: http://dx.doi.org/10.13039/100011703

Keywords

abdominal CT, anxiety, kidney cancer, psychosocial harms, screening, Humans, Male, Female, Lung Neoplasms, Tomography, X-Ray Computed, Middle Aged, Aged, Early Detection of Cancer, Feasibility Studies, Quality of Life, Surveys and Questionnaires, Radiography, Thoracic, Radiography, Abdominal, Anxiety, Kidney Neoplasms

Journal Title

BJU Int

Conference Name

Journal ISSN

1464-4096
1464-410X

Volume Title

Publisher

Wiley
Sponsorship
Yorkshire Cancer Research (L403C)
Cancer Research UK (C96/A25177)