Looking back on the alternative complement pathway.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Lachmann, Peter J
Abstract
The alternative pathway of complement originated from the Properdin pathway originally described by the Pillemer laboratory in the 1950s. This work generated great controversy and it took several decades for a consensus on its components, its reaction sequence and its functions to emerge. This paper reviews this history and attempts to clarify some of the ambiguities that remain.
Description
Keywords
Alternative pathway, Complement, Properdin, Animals, Complement Pathway, Alternative, History, 20th Century, History, 21st Century, Humans, Properdin
Journal Title
Immunobiology
Conference Name
Journal ISSN
0171-2985
1878-3279
1878-3279
Volume Title
223
Publisher
Elsevier
