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Better together: the role of IFIT protein-protein interactions in the antiviral response.

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cam.issuedOnline2018-09-20
dc.contributor.authorMears, Harriet V
dc.contributor.authorSweeney, Trevor R
dc.contributor.orcidSweeney, Trevor [0000-0003-4016-7326]
dc.date.accessioned2018-12-01T00:31:21Z
dc.date.available2018-12-01T00:31:21Z
dc.date.issued2018-11
dc.description.abstractThe interferon-induced proteins with tetratricopeptide repeats (IFITs) are a family of antiviral proteins conserved throughout all vertebrates. IFIT1 binds tightly to non-self RNA, particularly capped transcripts lacking methylation on the first cap-proximal nucleotide, and inhibits their translation by out-competing the cellular translation initiation apparatus. This exerts immense selection pressure on cytoplasmic RNA viruses to maintain mechanisms that protect their messenger RNA from IFIT1 recognition. However, it is becoming increasingly clear that protein-protein interactions are necessary for optimal IFIT function. Recently, IFIT1, IFIT2 and IFIT3 have been shown to form a functional complex in which IFIT3 serves as a central scaffold to regulate and/or enhance the antiviral functions of the other two components. Moreover, IFITs interact with other cellular proteins to expand their contribution to regulation of the host antiviral response by modulating innate immune signalling and apoptosis. Here, we summarize recent advances in our understanding of the IFIT complex and review how this impacts on the greater role of IFIT proteins in the innate antiviral response.
dc.format.mediumPrint-Electronic
dc.identifier.doi10.17863/CAM.33530
dc.identifier.eissn1465-2099
dc.identifier.issn0022-1317
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/286220
dc.languageeng
dc.language.isoeng
dc.publisherMicrobiology Society
dc.publisher.urlhttp://dx.doi.org/10.1099/jgv.0.001149
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectIFIT
dc.subjectantiviral response
dc.subjectinterferon
dc.subjectAnimals
dc.subjectHumans
dc.subjectImmunity, Innate
dc.subjectImmunologic Factors
dc.subjectProtein Binding
dc.subjectProtein Interaction Maps
dc.subjectProtein Multimerization
dc.subjectProteins
dc.subjectRNA Viruses
dc.subjectTetratricopeptide Repeat
dc.subjectVertebrates
dc.titleBetter together: the role of IFIT protein-protein interactions in the antiviral response.
dc.typeArticle
dcterms.dateAccepted2018-08-27
prism.endingPage1477
prism.issueIdentifier11
prism.publicationDate2018
prism.publicationNameJ Gen Virol
prism.startingPage1463
prism.volume99
pubs.funder-project-idWellcome Trust (202471/Z/16/Z)
rioxxterms.licenseref.startdate2018-11
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1099/jgv.0.001149

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