Generation of the Maternal Low-Protein Rat Model for Studies of Metabolic Disorders.
Accepted version
Peer-reviewed
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Repository DOI
Change log
Authors
Ma, Dan
Ozanne, Susan E
Guest, Paul C
Abstract
Poor nutrition during pregnancy leads to an increased risk of metabolic disorders and other diseases in the offspring. This can be modelled in animals through manipulation of the maternal diet. One such model is the maternal low-protein rat which gives rise to offspring characterized by insulin resistance. This chapter gives a detailed protocol for generation of the maternal low-protein rat, which has been used in the study of several disorders including diabetes and psychiatric disorders.
Description
Keywords
Biomarkers, Diabetes, Insulin resistance, Low-protein rat, Metabolic programming, Psychiatric disorders, Animals, Dietary Proteins, Disease Models, Animal, Female, Maternal Exposure, Metabolic Diseases, Pregnancy, Prenatal Exposure Delayed Effects, Protein Deficiency, Rats
Journal Title
Methods Mol Biol
Conference Name
Journal ISSN
1064-3745
1940-6029
1940-6029
Volume Title
1735
Publisher
Springer New York
Publisher DOI
Sponsorship
MRC (MC_UU_00014/4)