Associations between a fetal imprinted gene allele score and late pregnancy maternal glucose concentrations
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Abstract
We hypothesised that some of the genetic risk for gestational diabetes (GDM) is due to the fetal genome affecting maternal glucose concentrations. Previously, we found associations between fetal IGF2 gene variants and maternal glucose concentrations in late pregnancy.
In the present study, we tested associations between SNP alleles from 15 fetal imprinted genes and maternal glucose concentrations in late pregnancy in the Cambridge Baby Growth and Wellbeing cohorts (1160 DNA trios).
Four fetal SNP alleles with the strongest univariate associations: paternally-transmitted IGF2 rs10770125 (P-value = 2 × 10
This study suggests that polymorphic variation in fetal imprinted genes, particularly in the IGF2/INS region, contribute a small but significant part to the risk of raised late pregnancy maternal glucose concentrations.
Description
Keywords
Journal Title
Conference Name
Journal ISSN
1878-1780
Volume Title
Publisher
Publisher DOI
Sponsorship
Medical Research Council (MC_UU_12015/2)
National Institute for Health Research (NIHR) (via West Anglia Comprehensive Local Research Network (CLRN)) (UKCRN 11822)
Cambridge University Hospitals NHS Foundation Trust (CUH)
NIHR Clinical Research Network Eastern (IRAS 67546 REC Ref: 11/EE/0068)
Biotechnology and Biological Sciences Research Council (BB/F02293X/1)
Medical Research Council (G0600717)
Medical Research Council (G1001995)
Medical Research Council (G0500733)
Diabetes UK (11/0004241)
Medical Research Council (G1001995/1)
Medical Research Council (G0500733/1)
Medical Research Council (G0600717/1)