Lipid Profiles from Dried Blood Spots Reveal Lipidomic Signatures of Newborns Undergoing Mild Therapeutic Hypothermia after Hypoxic-Ischemic Encephalopathy

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cam.issuedOnline2021-11-28
cam.orpheus.successTue Feb 01 19:02:20 GMT 2022 - Embargo updated*
dc.contributor.authorNixon, Rebekah
dc.contributor.authorIp, Ting Hin Richard
dc.contributor.authorJenkins, Benjamin
dc.contributor.authorYip, Ping K
dc.contributor.authorClarke, Paul
dc.contributor.authorPonnusamy, Vennila
dc.contributor.authorMichael-Titus, Adina T
dc.contributor.authorKoulman, Albert
dc.contributor.authorShah, Divyen K
dc.contributor.orcidJenkins, Benjamin [0000-0003-0038-9709]
dc.contributor.orcidClarke, Paul [0000-0001-6203-7632]
dc.contributor.orcidKoulman, Albert [0000-0001-9998-051X]
dc.date.accessioned2021-11-25T11:49:45Z
dc.date.available2021-11-25T11:49:45Z
dc.date.issued2021-11-28
dc.description.abstract<jats:p>Hypoxic-ischemic encephalopathy (HIE) is associated with perinatal brain injury, which may lead to disability or death. As the brain is a lipid-rich organ, various lipid species can be significantly impacted by HIE and these correlate with specific changes to the lipidomic profile in the circulation. Objective: To investigate the peripheral blood lipidomic signature in dried blood spots (DBS) from newborns with HIE. Using univariate analysis, multivariate analysis and sPLS-DA modelling, we show that newborns with moderate–severe HIE (n = 46) who underwent therapeutic hypothermia (TH) displayed a robust peripheral blood lipidomic signature comprising 29 lipid species in four lipid classes; namely phosphatidylcholine (PC), lysophosphatidylcholine (LPC), triglyceride (TG) and sphingomyelin (SM) when compared with newborns with mild HIE (n = 18). In sPLS-DA modelling, the three most discriminant lipid species were TG 50:3, TG 54:5, and PC 36:5. We report a reduction in plasma TG and SM and an increase in plasma PC and LPC species during the course of TH in newborns with moderate–severe HIE, compared to a single specimen from newborns with mild HIE. These findings may guide the research in nutrition-based intervention strategies after HIE in synergy with TH to enhance neuroprotection.</jats:p>
dc.description.sponsorshipNIHR Cambridge Biomedical Research Centre (146281) & Biotechnology and Biological Sciences Research Council (BB/P028195/1)
dc.identifier.doi10.17863/CAM.78582en
dc.identifier.eissn2072-6643
dc.identifier.issn2072-6643
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/331135
dc.publisherMDPI AG
dc.rightsAll rights reserved
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserved
dc.titleLipid Profiles from Dried Blood Spots Reveal Lipidomic Signatures of Newborns Undergoing Mild Therapeutic Hypothermia after Hypoxic-Ischemic Encephalopathy
dc.typeArticle
dcterms.dateAccepted2021-11-24
prism.publicationNameNutrients
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (146281)
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (146281)
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/P028195/1)
rioxxterms.licenseref.startdate2021-11-24
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review
rioxxterms.versionAM
rioxxterms.versionofrecord10.3390/nu13124301
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