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The Gastrointestinal Dysfunction Scale for Parkinson's Disease.

Accepted version
Peer-reviewed

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Type

Article

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Authors

Williams-Gray, Caroline H  ORCID logo  https://orcid.org/0000-0002-2648-9743

Abstract

BACKGROUND: Gastrointestinal dysfunction is an important feature of Parkinson's disease (PD), and there is increasing evidence that it may play a key role in the disease process. However, its assessment is limited by different tools and underlying differences in diagnostic criteria for gastrointestinal dysfunction. To date, there is no psychometric instrument for quantitative evaluation of gastrointestinal symptoms specifically designed for use in PD. OBJECTIVE: The objective of this study was to develop a self-report questionnaire-based instrument, the Gastrointestinal Dysfunction Scale for Parkinson's Disease, and to evaluate its psychometric properties. METHODS: We performed a literature review and conducted 3 focus groups to develop the Gastrointestinal Dysfunction Scale for Parkinson's Disease. Three hundred and sixteen patients with PD and 55 controls completed the Gastrointestinal Dysfunction Scale for Parkinson's Disease, the Non-Motor Symptom Scale, the Hospital Anxiety and Depression Scale, and a stool diary adapted from the Bristol Stool Chart. RESULTS: The Gastrointestinal Dysfunction Scale for Parkinson's Disease demonstrated good internal consistency (Cronbach's α = 0.82) and test-retest stability (0.79 < ICCs > 0.94). Correlation analyses supported good convergent and divergent validity. Receiver operating characteristic analysis demonstrated that a cutoff score of ≥9 on the Gastrointestinal Dysfunction Scale for Parkinson's Disease Constipation subscale discriminates between PD patients with and without constipation. CONCLUSIONS: The Gastrointestinal Dysfunction Scale for Parkinson's Disease is a novel disease-specific self-report tool to quantitatively assess the presence and severity of gastrointestinal dysfunction features in patients with PD, with strong reliability and validity. Further longitudinal studies are needed to demonstrate its utility in tracking gastrointestinal dysfunction in PD clinical cohorts. © 2021 International Parkinson and Movement Disorder Society.

Description

Keywords

GIDS-PD, Parkinson's disease, gastrointestinal, patient-report outcome measure, scale, Humans, Parkinson Disease, Psychometrics, ROC Curve, Reproducibility of Results, Surveys and Questionnaires

Journal Title

Mov Disord

Conference Name

Journal ISSN

0885-3185
1531-8257

Volume Title

36

Publisher

Wiley

Rights

All rights reserved
Sponsorship
Michael J. Fox Foundation (MJFF) (14912)
Parkinson's UK (via University of Oxford) (R45438/CN013)
Medical Research Council (MR/R007446/1)
Medical Research Council (MC_PC_17230)
National Institute for Health and Care Research (IS-BRC-1215-20014)