Circulating Tumor Cells: Come Together, Right Now, Over Metastasis.
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Peer-reviewed
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Abstract
Circulating tumor cells (CTC) are the source of metastases, but only an infinitesimal fraction of them eventually succeed in colonizing a distant organ. New results show that CD44-dependent aggregation in the circulation provides CTCs with cancer stem cell-like characteristics, suggesting an explanation for the low metastatic efficiency of CTCs, but also avenues for therapeutic intervention.See related article by Liu et al., p. 96.
Description
Journal Title
Cancer Discov
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Journal ISSN
2159-8274
2159-8290
2159-8290
Volume Title
9
Publisher
American Association for Cancer Research (AACR)
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Except where otherwised noted, this item's license is described as All rights reserved
Sponsorship
Medical Research Council (MC_UU_12022/7)
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MRC (MR/N501876/1)
MRC (MR/N501876/1)
MRC (unknown)
MRC (MR/N501876/1)
MRC (MR/N501876/1)