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Exploration of a panel of urine biomarkers of kidney disease in two paediatric cohorts with Type 1 diabetes mellitus of differing duration.

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cam.issuedOnline2022-05-12
dc.contributor.authorZeni, Letizia
dc.contributor.authorNorden, Anthony GW
dc.contributor.authorPrandi, Elena
dc.contributor.authorCanepa, Carolina
dc.contributor.authorBurling, Keith
dc.contributor.authorSimpson, Katherine
dc.contributor.authorFelappi, Barbara
dc.contributor.authorPlebani, Alessandro
dc.contributor.authorCancarini, Giovanni
dc.contributor.authorFerraro, Pietro Manuel
dc.contributor.authorFraser, Donald
dc.contributor.authorUnwin, Robert J
dc.contributor.orcidZeni, Letizia [0000-0001-9221-5698]
dc.date.accessioned2022-06-14T01:02:50Z
dc.date.available2022-06-14T01:02:50Z
dc.date.issued2022-05-12
dc.date.updated2022-06-14T01:02:49Z
dc.description.abstractBACKGROUND: The pathogenesis of diabetic kidney disease (DKD) is complex and involves both glomerular and tubular dysfunction. A global assessment of kidney function is necessary to stage DKD, a progressive kidney disease that is likely to begin in childhood. The present study evaluated whether kidney injury biomarkers identified as early DKD biomarkers in adults have any prognostic value in the very early stages of childhood diabetes. METHODS: We measured urine free Retinol-binding protein 4 (UfRBP4), albumin (UAlb), Kidney injury molecule-1 (KIM-1) and the microRNAs miR-155, miR-126 and miR-29b in two cohorts of paediatric T1DM patients without evidence of DKD, but with diabetes of short-duration, ≤ 2.5 years (SD, n = 25) or of long-duration, ≥ 10 years (LD, n = 29); non-diabetic siblings (H, n = 26) were recruited as controls. A p value < 0.05 was considered significant for all results. RESULTS: UfRBP4 and UAlb were not significantly different across the three groups. No differences were found in KIM-1 excretion between any of the three groups. UfRBP4 was correlated with UAlb in all three groups (r 0.49; p < 0.001), whereas KIM-1 showed no correlation with albumin excretion. Among microRNAs, miR-29b was higher in all diabetic children compared with the H control group (p = 0.03), whereas miR-155 and miR-126 were not significantly different. No differences were found between the SD and LD groups for all three microRNAs. No associations were identified between these biomarkers with sex, age, BMI, eGFR, T1DM duration or glycaemic control. CONCLUSIONS: UfRBP4, KIM-1, miR-155, and miR-126 were unaffected by the presence and duration of diabetes, whereas miR-29b showed a modest elevation in diabetics, regardless of duration. These data support the specificity of a panel of urine biomarkers as DKD biomarkers, rather than any relationship to diabetes per se or its duration, and not as early DKD biomarkers in a paediatric setting.
dc.identifier.doi10.17863/CAM.85461
dc.identifier.eissn1758-5996
dc.identifier.issn1758-5996
dc.identifier.other35550634
dc.identifier.otherPMC9097324
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/338052
dc.languageeng
dc.language.isoeng
dc.publisherSpringer Science and Business Media LLC
dc.publisher.urlhttp://dx.doi.org/10.1186/s13098-022-00839-4
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourcenlmid: 101488958
dc.sourceessn: 1758-5996
dc.subjectAlbuminuria
dc.subjectDiabetic kidney disease
dc.subjectKidney injury molecule-1
dc.subjectType 1 diabetes mellitus
dc.subjectUrinary biomarkers
dc.subjectUrine free retinol-binding protein 4
dc.subjectmicroRNAs
dc.titleExploration of a panel of urine biomarkers of kidney disease in two paediatric cohorts with Type 1 diabetes mellitus of differing duration.
dc.typeArticle
dcterms.dateAccepted2022-04-26
prism.issueIdentifier1
prism.publicationNameDiabetol Metab Syndr
prism.volume14
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1186/s13098-022-00839-4

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