The effect of perceptual expectation on repetition suppression to faces is not modulated by variation in autistic traits


Type
Article
Change log
Authors
Ewbank, MP 
von dem Hagen, EAH 
Powell, TE 
Henson, RN 
Calder, AJ 
Abstract

There is substantial variation in the magnitude of the repetition suppression (RS) effects across individuals; however the causes of this variation remain unclear. In a recent study, we found that RS in occipitotemporal cortex was negatively related to individual variation in autistic traits in a neurotypical population. Recent proposals have considered autistic behaviours within a Bayesian framework, suggesting that individuals with autism may have 'attenuated priors' (i.e., their perception is less influenced by prior information). Predictive coding represents a neural instantiation of Bayesian inference, and characterises RS as reduction in prediction error between 'top-down' (prior beliefs) and 'bottom-up' (stimulus related) inputs. In accordance with this, evidence shows that RS is greater when repetition of a stimulus is expected relative to when it is unexpected. Here, using an established paradigm which manipulates the probability of stimulus repetition, we investigated the effect of perceptual expectation on RS in a group of neurotypical individuals varying on a measure of autistic traits. We predicted that the magnitude of the perceptual expectation effect would be negatively related to individual differences in autistic traits. We found a significant effect of perceptual expectation on RS in face-selective regions (i.e., greater RS when repetitions were expected relative to unexpected). However, there was no evidence of a relationship between autistic traits and the magnitude of this effect in any face-selective region of interest (ROI). These findings provide a challenge for the proposal that autism spectrum conditions (ASC) may be associated with the attenuated influence of prior information.

Description
Keywords
autism, fusiform-face-area, predictive-coding, priors, fMRI-adaptation
Journal Title
Cortex
Conference Name
Journal ISSN
0010-9452
1973-8102
Volume Title
80
Publisher
Elsevier
Sponsorship
MRC (unknown)
Medical Research Council (MC_U105579226)
This work was supported by the UK Medical Research Council under project codes MC-A060-5PQ50 (Andrew J. Calder) and MC_US_A060_0046 (Richard N. Henson).