Relating the Biogenesis and Function of P bodies in Drosophila to Human Disease

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Wilby, Elise 

Abstract: Drosophila has been a premier model organism for over a century and many discoveries in flies have furthered our understanding of human disease. Flies have been successfully applied to a wide range of health-based research spanning from behavioural addiction, to dysplasia, to RNA dysregulation and protein misfolding. Recently, Drosophila tissues have been used to study biomolecular condensates and their role in multicellular systems. Identified in a wide range of plant and animal species, biomolecular condensates are dynamic, non-membrane bound sub-compartments that have been observed and characterised in the cyto-plasm and nucleus of many cell types. Condensate biology has exciting research prospects because of their di-verse roles within cells, links to disease, and potential for therapeutics. In this review, we will discuss pro-cessing bodies (P bodies), a conserved biomolecular condensate, with a particular interest in how Drosophila can be applied to advance our understanding of condensate biogenesis and their role in disease.

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Wellcome Trust (200734/Z/16/Z)
Biotechnology and Biological Sciences Research Council (2274380)