The role of epoxyeicosatrienoic acids in the cardiovascular system.


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Authors
Yang, L 
Mäki-Petäjä, K 
Wilkinson, IB 
Abstract

There is increasing evidence suggesting that epoxyeicosatrienoic acids (EETs) play an important role in cardioprotective mechanisms. These include regulating vascular tone, modulating inflammatory responses, improving cardiomyocyte function and reducing ischaemic damage, resulting in attenuation of animal models of cardiovascular risk factors. This review discusses the current knowledge on the role of EETs in endothelium-dependent control of vascular tone in the healthy and in subjects with cardiovascular risk factors, and considers the pharmacological potential of targeting this pathway.

Description
Keywords
cardiovascular system, epoxyeicosatrienoic acids, soluble epoxide hydrolase inhibitor, vascular tone, Animals, Cardiovascular Diseases, Cardiovascular Physiological Phenomena, Humans, Hydroxyeicosatetraenoic Acids, Molecular Targeted Therapy
Journal Title
Br J Clin Pharmacol
Conference Name
Journal ISSN
0306-5251
1365-2125
Volume Title
80
Publisher
Wiley
Sponsorship
National Institute for Health Research (NIHR) (via West Anglia Comprehensive Local Research Network (CLRN)) (14339)
Technology Strategy Board (101024 TP 9157-61188)
British Heart Foundation (None)
Dr. Lucy Yang is funded by the Wellcome Trust TMAT programme, the Sackler fellowship, and Clare College Research Expenses Fund. Professor Ian Wilkinson and Dr. Joseph Cheriyan are both funded by the Cambridge Biomedical Research Centre. Professor Ian Wilkinson and Dr. Carmel McEniery are both funded by the British Heart Foundation.