In this paper, 3D weakly compressible and incompressible Smoothed Particle Hydrodynamics (WCSPH & ISPH) models are used to study dam-break flows impacting on either a fixed or a movable structure. First, the two models’ performances are compared in terms of CPU time efficiency and numerical accuracy, as well as the water surface shapes and pressure fields. Then, they are applied to investigate dam-break flow interactions with structures placed in the path of the flood. The study found that the ISPH modelling approach is slightly superior to the WCSPH approach, since more stable particle motion and pressure distribution can be achieved with reasonable CPU load.