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Combenefit: an interactive platform for the analysis and visualization of drug combinations.

Published version
Peer-reviewed

Repository DOI


Type

Article

Change log

Authors

Di Veroli, Giovanni Y 
Fornari, Chiara 
Wang, Dennis 
Mollard, Séverine 
Bramhall, Jo L 

Abstract

MOTIVATION: Many drug combinations are routinely assessed to identify synergistic interactions in the attempt to develop novel treatment strategies. Appropriate software is required to analyze the results of these studies. RESULTS: We present Combenefit, new free software tool that enables the visualization, analysis and quantification of drug combination effects in terms of synergy and/or antagonism. Data from combinations assays can be processed using classical Synergy models (Loewe, Bliss, HSA), as single experiments or in batch for High Throughput Screens. This user-friendly tool provides laboratory scientists with an easy and systematic way to analyze their data. The companion package provides bioinformaticians with critical implementations of routines enabling the processing of combination data. AVAILABILITY AND IMPLEMENTATION: Combenefit is provided as a Matlab package but also as standalone software for Windows (http://sourceforge.net/projects/combenefit/). CONTACT: Giovanni.DiVeroli@cruk.cam.ac.uk SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

Description

Keywords

Computational Biology, Drug Combinations, Drug Delivery Systems, High-Throughput Nucleotide Sequencing, Software, User-Computer Interface

Journal Title

Bioinformatics

Conference Name

Journal ISSN

1367-4803
1367-4811

Volume Title

32

Publisher

Oxford University Press (OUP)
Sponsorship
Cancer Research UK (CB4270)
This work has been supported by the Cancer Research UK grant C14303/A17197