Advances in Applying Computer-Aided Drug Design for Neurodegenerative Diseases


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Authors
Abstract

Neurodegenerative diseases (NDs) including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and Huntington’s disease are incurable and affect millions of people worldwide. The development of treatments for this unmet clinical need is a major global research challenge. Computer-aided drug design (CADD) methods minimize the huge number of ligands that could be screened in biological assays, reducing the cost, time, and effort required to develop new drugs. In this review, we provide an introduction to CADD and examine the progress in applying CADD and other molecular docking studies to NDs. We provide an updated overview of potential therapeutic targets for various NDs and discuss some of the advantages and disadvantages of these tools.

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Keywords
neurodegeneration, drug discovery, CADD, dementia, brain diseases, CNS disorders, Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, Huntington’s disease
Journal Title
International Journal of Molecular Sciences
Conference Name
Journal ISSN
1422-0067
Volume Title
22
Publisher
MDPI