The dawn of spatial omics.


Type
Article
Change log
Authors
Abstract

Spatial omics has been widely heralded as the new frontier in life sciences. This term encompasses a wide range of techniques that promise to transform many areas of biology and eventually revolutionize pathology by measuring physical tissue structure and molecular characteristics at the same time. Although the field came of age in the past 5 years, it still suffers from some growing pains: barriers to entry, robustness, unclear best practices for experimental design and analysis, and lack of standardization. In this Review, we present a systematic catalog of the different families of spatial omics technologies; highlight their principles, power, and limitations; and give some perspective and suggestions on the biggest challenges that lay ahead in this incredibly powerful-but still hard to navigate-landscape.

Description
Keywords
Genomics, Research Design, Humans, Animals, Mice, Organ Specificity
Journal Title
Science
Conference Name
Journal ISSN
0036-8075
1095-9203
Volume Title
381
Publisher
American Association for the Advancement of Science (AAAS)
Sponsorship
National Institute for Health and Care Research (IS-BRC-1215-20014)
Wellcome Trust (110161/Z/15/Z)
Cancer Research UK (22582)