Red-light modulated ortho-chloro azobenzene photoswitch for peptide stapling via aromatic substitution
jats:pDevelopment and proof-of-concept for a photoswitchable peptide staple with the ability to trigger a major change in binding affinity upon visible light irradiation.</jats:p>
Acknowledgements: M. K. acknowledges EPSRC for funding (SynTech EP/S024220/1). F. J. P. A. gratefully acknowledges both postdoctoral fellowships from Fundación Ramón Areces (reference BEVP31A6160) and Marie Skłodowska-Curie Individual Fellowships (MSCA-IF-2020, grant number 101025271). N. A. acknowledges a studentship from AstraZeneca. T. S. acknowledges EU funding by the H2020-MSCA-RISE-2020 through the ALISE project (grant 101007256). The Spring group research was supported by grants from UKRI. For the purpose of Open Access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript (AAM) version arising. Authors are also grateful to Dr Rohan Eapen for the purification of MDM2 protein, Dr Katherine Stott for interpretation of CD spectra and the NMR team at Cambridge for measuring advanced NMR experiments (Andrew Mason, Duncan Howe and Peter Gierth).
Fundación Ramón Areces (BEVP31A6160)
EPSRC Centre for Doctoral Training in Technology Enhanced Chemical Synthesis (EP/S024220/1)