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Species Choice and Model Use: Reviving Research on Human Development.

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Peer-reviewed

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Change log

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Abstract

While model organisms have had many historians, this article places studies of humans, and particularly our development, in the politics of species choice. Human embryos, investigated directly rather than via animal surrogates, have gone through cycles of attention and neglect. In the past 60 years they moved from the sidelines to center stage. Research was resuscitated in anatomy, launched in reproductive biomedicine, molecular genetics, and stem-cell science, and made attractive in developmental biology. I explain this surge of interest in terms of rivalry with models and reliance on them. The greater involvement of medicine in human reproduction, especially through in vitro fertilization, gave access to fresh sources of material that fed critiques of extrapolation from mice and met demands for clinical relevance or "translation." Yet much of the revival depended on models. Supply infrastructures and digital standards, including biobanks and virtual atlases, emulated community resources for model organisms. Novel culture, imaging, molecular, and postgenomic methods were perfected on less precious samples. Toing and froing from the mouse affirmed the necessity of the exemplary mammal and its insufficiency justified inquiries into humans. Another kind of model-organoids and embryo-like structures derived from stem cells-enabled experiments that encouraged the organization of a new field, human developmental biology. Research on humans has competed with and counted on models.

Description

Acknowledgements: I am most grateful to Alfonso Martinez Arias for discussions and opportunities to present. I thank Alain Chédotal, Andrew Copp, Susan Lindsay, Kathy Niakan, and Olivier Pourquié for being interviewed or talking more informally; Andrew Copp (HDBR), Elizabeth Lockett (HDAC), Christoph Viebahn (Göttingen), Taylor Henning (Wayne State), Jessica Murphy (Countway Library), and Sara Gunasekara and Sangeet Gill (UC Davis) for providing access to materials; Alfonso Martinez Arias, Dmitriy Myelnikov, Kathy Niakan, Peter Braude, Scott Gilbert, Christoph Viebahn, Martin Johnson, Nicolas Rasmussen, and an anonymous referee for comments on drafts; Ian Bolton and Adrian Newman (AVMG) for making the figures; and the Leverhulme Trust for part-funding the research (MRF-2020-037). I learned much from participation in events organized by Cambridge Reproduction, the Cambridge Festival, and the Human Developmental Biology Initiative, and most from feedback on a talk at the Cold Spring Harbor Asia meeting on Awaji Island in March 2023.

Keywords

Biobanks, Digital anatomy, Human developmental biology, Model organisms, Postgenomic science, Stem-cell-based embryo models, Humans, Animals, History, 20th Century, Mice, Developmental Biology, Embryo Research, Models, Animal, History, 21st Century, Human Development

Journal Title

J Hist Biol

Conference Name

Journal ISSN

0022-5010
1573-0387

Volume Title

57

Publisher

Springer Science and Business Media LLC
Sponsorship
Leverhulme Trust (MRF-2020-037)
Leverhulme Trust (MRF-2020-037)