Origin and function of the yolk sac in primate embryogenesis


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Authors
Ross, Connor 
Boroviak, Thorsten E.  ORCID logo  https://orcid.org/0000-0001-8703-8949
Abstract

Abstract: Human embryogenesis is hallmarked by two phases of yolk sac development. The primate hypoblast gives rise to a transient primary yolk sac, which is rapidly superseded by a secondary yolk sac during gastrulation. Moreover, primate embryos form extraembryonic mesoderm prior to gastrulation, in contrast to mouse. The function of the primary yolk sac and the origin of extraembryonic mesoderm remain unclear. Here, we hypothesise that the hypoblast-derived primary yolk sac serves as a source for early extraembryonic mesoderm, which is supplemented with mesoderm from the gastrulating embryo. We discuss the intricate relationship between the yolk sac and the primate embryo and highlight the pivotal role of the yolk sac as a multifunctional hub for haematopoiesis, germ cell development and nutritional supply.

Description

Funder: Wellcome Trust (Wellcome); doi: https://doi.org/10.13039/100004440

Keywords
Perspective, /631/136, /631/443/494, perspective
Journal Title
Nature Communications
Conference Name
Journal ISSN
2041-1723
Volume Title
11
Publisher
Nature Publishing Group UK