Understanding ethnic diversity in open dementia neuroimaging data sets

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Authors
Heng, Nicholas Yew Wei  ORCID logo  https://orcid.org/0000-0003-4190-1780
Abstract

jats:titleAbstract</jats:title> jats:pEthnic differences in dementia are increasingly recognized in epidemiological measures and diagnostic biomarkers. Nonetheless, ethnic diversity remains limited in many study populations. Here, we provide insights into ethnic diversity in open-access neuroimaging dementia data sets. Data sets comprising dementia populations with available data on ethnicity were included. Statistical analyses of sample and effect sizes were based on the Cochrane Handbook. Nineteen databases were included, with 17 studies of healthy groups or a combination of diagnostic groups if breakdown was unavailable and 12 of mild cognitive impairment and dementia groups. Combining all studies on dementia patients, the largest ethnic group was Caucasian (20 547 participants), with the next most common being Afro-Caribbean (1958), followed by Asian (1211). The smallest effect size detectable within the Caucasian group was 0.03, compared to Afro-Caribbean (0.1) and Asian (0.13). Our findings quantify the lack of ethnic diversity in openly available dementia data sets. More representative data would facilitate the development and validation of biomarkers relevant across ethnicities.</jats:p>

Description

Funder: National Institute for Health and Care Research; DOI: https://doi.org/10.13039/100009250


Funder: Department of Health and Social Care; DOI: https://doi.org/10.13039/501100000276

Keywords
32 Biomedical and Clinical Sciences, 5202 Biological Psychology, 3202 Clinical Sciences, 3209 Neurosciences, 52 Psychology, Clinical Research, Acquired Cognitive Impairment, Neurosciences, Neurodegenerative, Alzheimer's Disease, Brain Disorders, Aging, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Dementia, Neurological
Journal Title
Brain Communications
Conference Name
Journal ISSN
2632-1297
2632-1297
Volume Title
5
Publisher
Oxford University Press (OUP)
Sponsorship
Wellcome Trust (221633/Z/20/Z)
MRC (via University College London (UCL)) (MR/X005674/1)
Medical Research Council (MR/X005674/1)
Cambridge Biomedical Research Centre