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Dissemination of Mycobacterium abscessus via global transmission networks.

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cam.issuedOnline2021-09-20
dc.contributor.authorRuis, Christopher
dc.contributor.authorBryant, Josephine M
dc.contributor.authorBell, Scott C
dc.contributor.authorThomson, Rachel
dc.contributor.authorDavidson, Rebecca M
dc.contributor.authorHasan, Nabeeh A
dc.contributor.authorvan Ingen, Jakko
dc.contributor.authorStrong, Michael
dc.contributor.authorFloto, R Andres
dc.contributor.authorParkhill, Julian
dc.contributor.orcidFloto, Andres [0000-0002-2188-5659]
dc.contributor.orcidParkhill, Julian [0000-0002-7069-5958]
dc.date.accessioned2021-11-06T00:31:07Z
dc.date.available2021-11-06T00:31:07Z
dc.date.issued2021-10
dc.description.abstractMycobacterium abscessus, a multidrug-resistant nontuberculous mycobacterium, has emerged as a major pathogen affecting people with cystic fibrosis (CF). Although originally thought to be acquired independently from the environment, most individuals are infected with one of several dominant circulating clones (DCCs), indicating the presence of global transmission networks of M. abscessus. How and when these clones emerged and spread globally is unclear. Here, we use evolutionary analyses of isolates from individuals both with and without CF to reconstruct the population history, spatiotemporal spread and recent transmission networks of the DCCs. We demonstrate synchronous expansion of six unrelated DCCs in the 1960s, a period associated with major changes in CF care and survival. Each of these clones has spread globally as a result of rare intercontinental transmission events. We show that the DCCs, but not environmentally acquired isolates, exhibit a specific smoking-associated mutational signature and that current transmission networks include individuals both with and without CF. We therefore propose that the DCCs initially emerged in non-CF populations but were then amplified and spread through the CF community. While individuals with CF are probably the most permissive host, non-CF individuals continue to play a key role in transmission networks and may facilitate long-distance transmission.
dc.description.sponsorshipFunding for this work was provided by The Wellcome Trust (investigator award no. 107032/Z/15/Z to R.A.F.), Fondation Botnar (Programme grant no. 6063) and the UK CF Trust (Innovation Hub award no. 001; Strategic Research Centre award no. 010). M.S., N.A.H. and R.M.D. acknowledge the Cystic Fibrosis Foundation for funding.
dc.identifier.doi10.17863/CAM.77815
dc.identifier.eissn2058-5276
dc.identifier.issn2058-5276
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/330372
dc.languageeng
dc.language.isoeng
dc.publisherNature Research
dc.publisher.urlhttp://dx.doi.org/10.1038/s41564-021-00963-3
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCystic Fibrosis
dc.subjectGenome, Bacterial
dc.subjectGlobal Health
dc.subjectHumans
dc.subjectLung
dc.subjectMutation
dc.subjectMycobacterium Infections, Nontuberculous
dc.subjectMycobacterium abscessus
dc.subjectPhylogeny
dc.subjectSmokers
dc.titleDissemination of Mycobacterium abscessus via global transmission networks.
dc.typeArticle
dcterms.dateAccepted2021-08-18
prism.endingPage1288
prism.issueIdentifier10
prism.publicationNameNature Microbiology
prism.startingPage1279
prism.volume6
pubs.funder-project-idWellcome Trust (107032/Z/15/Z)
pubs.funder-project-idWellcome Trust (110224/Z/15/Z)
rioxxterms.licenseref.startdate2021-08-18
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1038/s41564-021-00963-3

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