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Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition.

Accepted version
Peer-reviewed

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Type

Article

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Authors

Obón-Santacana, Mireia  ORCID logo  https://orcid.org/0000-0003-4646-3513
Luján-Barroso, Leila 
Freisling, Heinz 
Naudin, Sabine 
Boutron-Ruault, Marie-Christine  ORCID logo  https://orcid.org/0000-0002-5956-5693

Abstract

Four epidemiologic studies have assessed the association between nut intake and pancreatic cancer risk with contradictory results. The present study aims to investigate the relation between nut intake (including seeds) and pancreatic ductal adenocarcinoma (PDAC) risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to estimate hazards ratio (HR) and 95% confidence intervals (95% CI) for nut intake and PDAC risk. Information on intake of nuts was obtained from the EPIC country-specific dietary questionnaires. After a mean follow-up of 14 years, 476,160 participants were eligible for the present study and included 1,283 PDAC cases. No association was observed between consumption of nuts and PDAC risk (highest intake vs nonconsumers: HR, 0.89; 95% CI, 0.72-1.10; p-trend = 0.70). Furthermore, no evidence for effect-measure modification was observed when different subgroups were analyzed. Overall, in EPIC, the highest intake of nuts was not statistically significantly associated with PDAC risk.

Description

Keywords

EPIC, diet, intake, nuts, pancreatic cancer, prospective cohort study, seeds, Carcinoma, Pancreatic Ductal, Diet, Europe, Female, Humans, Male, Middle Aged, Nuts, Pancreatic Neoplasms, Proportional Hazards Models, Prospective Studies, Risk Factors, Seeds, Surveys and Questionnaires

Journal Title

Int J Cancer

Conference Name

Journal ISSN

0020-7136
1097-0215

Volume Title

146

Publisher

Wiley

Rights

All rights reserved
Sponsorship
Medical Research Council (MC_UU_12015/1)
Department of Health (via National Institute for Health Research (NIHR)) (NF-SI-0617-10149)
Medical Research Council (MR/N003284/1)
Medical Research Council (G0401527)
Medical Research Council (G1000143)
Medical Research Council (G0401527/1)
Cancer Research Uk (None)
Cancer Research UK (C570/A16491 and C8221/A19170 to EPIC-Oxford), Medical Research Council (MR/M012190/1 to EPIC-Oxford) (United Kingdom).