Peroxide-cleavable linkers for antibody–drug conjugates †
Published version
Peer-reviewed
Repository URI
Repository DOI
Loading...
Type
Change log
Authors
Abstract
Antibody–drug conjugates containing peroxide-cleavable arylboronic acid linkers are described, which target the high levels of reactive oxygen species (ROS) in cancer. The arylboronic acid linkers rapidly release a payload in the presence of hydrogen peroxide, but remain stable in plasma. Anti-HER2 and PD-L1 peroxide-cleavable ADCs exhibited potent cytotoxicity in vitro.
Description
Keywords
Is Part Of
Publisher
The Royal Society of Chemistry
Publisher DOI
Rights and licensing
Except where otherwised noted, this item's license is described as http://creativecommons.org/licenses/by/3.0/
Sponsorship
Engineering and Physical Sciences Research Council (Unassigned)
Biotechnology and Biological Sciences Research Council (Unassigned)
Medical Research Council (Unassigned)
Biotechnology and Biological Sciences Research Council (Unassigned)
Medical Research Council (Unassigned)