Peroxide-cleavable linkers for antibody–drug conjugates †
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Peer-reviewed
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Authors
Greenwood, Ryan D.
Tiberghien, Arnaud
Abstract
Antibody–drug conjugates containing peroxide-cleavable arylboronic acid linkers are described, which target the high levels of reactive oxygen species (ROS) in cancer. The arylboronic acid linkers rapidly release a payload in the presence of hydrogen peroxide, but remain stable in plasma. Anti-HER2 and PD-L1 peroxide-cleavable ADCs exhibited potent cytotoxicity in vitro.
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The Royal Society of Chemistry
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Engineering and Physical Sciences Research Council (Unassigned)
Biotechnology and Biological Sciences Research Council (Unassigned)
Medical Research Council (Unassigned)
Biotechnology and Biological Sciences Research Council (Unassigned)
Medical Research Council (Unassigned)