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Technical validation studies of a dual-wavelength LED-based photoacoustic and ultrasound imaging system.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Joseph, James 
Ajith Singh, Mithun Kuniyil 
Sato, Naoto 

Abstract

Recent advances in high power, pulsed, light emitting diodes (LEDs) have shown potential as fast, robust and relatively inexpensive excitation sources for photoacoustic imaging (PAI), yet systematic characterization of performance for biomedical imaging is still lacking. We report here technical and biological validation studies of a commercial dual-wavelength LED-based PAI and ultrasound system. Phantoms and small animals were used to assess temporal precision. In phantom studies, we found high temporal stability of the LED-based PAI system, with no significant drift in performance observed during 6 h of operation or over 30 days of repeated measurements. In vivo dual-wavelength imaging was able to map the dynamics of changes in blood oxygenation during oxygen-enhanced imaging and reveal the kinetics of indocyanine green contrast agent inflow after intravenous administration (Tmax∼6 min). Taken together, these studies indicate that LED-based excitation could be promising for future application in functional and molecular PAI.

Description

Keywords

Photoacoustics, Phantoms, Light Emitting Diodes

Journal Title

Photoacoustics

Conference Name

Journal ISSN

2213-5979

Volume Title

22

Publisher

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