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Functional network dynamics in a neurodevelopmental disorder of known genetic origin.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Hawkins, Erin 
Akarca, Danyal 
Zhang, Mengya 
Woolrich, Mark 

Abstract

Dynamic connectivity in functional brain networks is a fundamental aspect of cognitive development, but we have little understanding of the mechanisms driving variability in these networks. Genes are likely to influence the emergence of fast network connectivity via their regulation of neuronal processes, but novel methods to capture these rapid dynamics have rarely been used in genetic populations. The current study redressed this by investigating brain network dynamics in a neurodevelopmental disorder of known genetic origin, by comparing individuals with a ZDHHC9-associated intellectual disability to individuals with no known impairment. We characterised transient network dynamics using a Hidden Markov Model (HMM) on magnetoencephalography (MEG) data, at rest and during auditory oddball stimulation. The HMM is a data-driven method that captures rapid patterns of coordinated brain activity recurring over time. Resting-state network dynamics distinguished the groups, with ZDHHC9 participants showing longer state activation and, crucially, ZDHHC9 gene expression levels predicted the group differences in dynamic connectivity across networks. In contrast, network dynamics during auditory oddball stimulation did not show this association. We demonstrate a link between regional gene expression and brain network dynamics, and present the new application of a powerful method for understanding the neural mechanisms linking genetic variation to cognitive difficulties.

Description

Keywords

atypical brain development, cognitive development, functional connectivity, human genetics, magnetoencephalography, Acyltransferases, Adolescent, Adult, Attention, Auditory Perception, Cerebral Cortex, Connectome, Gene Expression, Humans, Intellectual Disability, Magnetoencephalography, Male, Markov Chains, Nerve Net, Young Adult

Journal Title

Hum Brain Mapp

Conference Name

Journal ISSN

1065-9471
1097-0193

Volume Title

41

Publisher

Wiley
Sponsorship
Medical Research Council (MC_UU_00005/2)
Medical Research Council (MC_UU_00005/16)