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Higher Incidence but Similar Outcomes from Bloodstream Infections in People with Type 2 Diabetes Mellitus: A Retrospective Case-Controlled Analysis

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cam.depositDate2022-01-01
dc.contributor.authorBryce, AN
dc.contributor.authorPhillips, R
dc.contributor.authorSkittrall, JP
dc.contributor.authorChakera, AJ
dc.contributor.authorMcLoughlin, JK
dc.contributor.authorSargent, CS
dc.contributor.orcidSkittrall, Jordan [0000-0002-8228-3758]
dc.date.accessioned2022-01-13T00:30:43Z
dc.date.available2022-01-13T00:30:43Z
dc.date.issued2020-10
dc.date.updated2022-01-01T16:34:21Z
dc.description.abstractAims: People with type 2 diabetes mellitus are more susceptible to infections. This study aimed to compare the microbiology, incidence and clinical outcome of bloodstream infections (BSIs) in people with type 2 diabetes and matched controls amongst a cohort of hospital inpatients in the United Kingdom. Methods: A retrospective analysis was conducted on all positive blood cultures obtained over a one-year period, identifying inpatients with type 2 diabetes and BSIs (n = 151). Matched controls were collated from the same cohort. Admission data were obtained from clinical coding. Patient outcomes were analysed in terms of 90-day mortality, length of stay (LOS) and admission rate to high or intensive dependency units (HDU/ICU). Microbial culture and clinical source of infection were compared between groups. Results: Patients with type 2 diabetes comprised 10.6% of admissions but 21.1% (n = 151) of analysed BSIs (OR: 2.27, p < .001). Similar 90-day mortality rates were seen between people with type 2 diabetes (D) and controls (C) (D: 23/151, C: 28/151, p = .54). Mean LOS was also similar (D: 19.8 days, C: 21.1 days p = .62). In both groups, Escherichia coli was the most commonly isolated organism (D: 64/173, C: 55/171) and the urinary tract the most common identified primary site of BSI (D: 47/151, C: 45/151). Conclusions: Whilst inpatients with type 2 diabetes have increased odds of experiencing BSIs, our single-centre study suggests a diagnosis of type 2 diabetes does not necessarily confer a worse outcome.
dc.identifier.doi10.17863/CAM.80109
dc.identifier.eissn2590-1702
dc.identifier.issn2590-1702
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/332664
dc.language.isoeng
dc.publisherElsevier BV
dc.publisher.departmentDepartment of Pathology
dc.publisher.urlhttp://dx.doi.org/10.1016/j.clinpr.2020.100030
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject32 Biomedical and Clinical Sciences
dc.subject3202 Clinical Sciences
dc.subjectDiabetes
dc.subjectInfectious Diseases
dc.subjectClinical Research
dc.subjectInfection
dc.subjectMetabolic and endocrine
dc.subject3 Good Health and Well Being
dc.titleHigher Incidence but Similar Outcomes from Bloodstream Infections in People with Type 2 Diabetes Mellitus: A Retrospective Case-Controlled Analysis
dc.typeArticle
prism.endingPage100030
prism.number100030
prism.publicationDate2020
prism.publicationNameClinical Infection in Practice
prism.startingPage100030
prism.volume7-8
pubs.funder-project-idMason Medical Research Trust (Unknown)
pubs.licence-display-nameApollo Repository Deposit Licence Agreement
pubs.licence-identifierapollo-deposit-licence-2-1
rioxxterms.typeJournal Article/Review
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1016/j.clinpr.2020.100030

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