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Breaking the loop in AML.

Published version
Peer-reviewed

Repository DOI


Type

Article

Change log

Authors

Abstract

In this issue of Blood1, Bamezai et al reveal an unexpected, moonlighting* function of the germ cell associated RNA binding protein, PIWIL4 in AML. The authors show a tumor-specific requirement for PIWIL4 in R-loop homeostasis. Loss of PIWIL4 in AML cells led to uncontrolled R-loop formation, transcriptional stalling, DNA damage and an enhanced sensitivity to ATR inhibition, findings that may inform future therapeutic approaches.

Description

Keywords

Humans, Leukemia, Myeloid, Acute, Genomics

Journal Title

Blood

Conference Name

Journal ISSN

0006-4971
1528-0020

Volume Title

Publisher

American Society of Hematology

Version History

Now showing 1 - 2 of 2
VersionDateSummary
2*
2023-07-17 13:38:35
Published version added
2023-05-24 00:30:14
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