A Continuous Multistep Process for the Preparation of 3-Bromo-2-Oxopropanal O-methyl Oxime as a Precursor to Access C4-Oxime-Substituted Thiazoles
cam.issuedOnline | 2018-06-26 | |
dc.contributor.author | Ley, SV | |
dc.contributor.author | Godineau, Edouard | |
dc.contributor.author | Battilocchio, Claudio | |
dc.contributor.author | Lehmann, Matthias | |
dc.contributor.author | Labes, Ricardo | |
dc.contributor.author | Birnoschi, letitia | |
dc.contributor.author | Subramanian, Srinivas | |
dc.contributor.author | Prasanna, CS | |
dc.contributor.author | Gorde, Amol | |
dc.contributor.author | Kalbagh, Mahesh | |
dc.contributor.author | Khade, Vivek | |
dc.contributor.author | Scherrer, Anton | |
dc.contributor.author | O'Sullivan, Anthony Cornelius | |
dc.contributor.orcid | Ley, Steven [0000-0002-7816-0042] | |
dc.contributor.orcid | Labes, Ricardo [0000-0003-4001-0775] | |
dc.date.accessioned | 2018-09-08T06:35:36Z | |
dc.date.available | 2018-09-08T06:35:36Z | |
dc.description.abstract | We report a strategy designed for the rapid and convergent assembly of C4-oxime substituted thiazoles. Our approach relied on 3-bromo-2-oxopropanal O-methyl oxime as a key building block. In particular, we describe a multistep continuous synthesis of this intermediate and demonstrate the advantages of our set-up upon scaling up. | |
dc.identifier.doi | 10.17863/CAM.27316 | |
dc.identifier.uri | https://www.repository.cam.ac.uk/handle/1810/279948 | |
dc.language.iso | eng | |
dc.title | A Continuous Multistep Process for the Preparation of 3-Bromo-2-Oxopropanal O-methyl Oxime as a Precursor to Access C4-Oxime-Substituted Thiazoles | |
dc.type | Article | |
dcterms.dateAccepted | 2018-06-13 | |
prism.publicationName | OPRD | |
pubs.funder-project-id | Engineering and Physical Sciences Research Council (EP/K009494/1) | |
pubs.funder-project-id | Engineering and Physical Sciences Research Council (EP/M004120/1) | |
rioxxterms.licenseref.startdate | 2018-06-13 | |
rioxxterms.licenseref.uri | http://creativecommons.org/licenses/by/4.0/ | |
rioxxterms.type | Journal Article/Review | |
rioxxterms.version | AM | |
rioxxterms.versionofrecord | 10.1021/acs/oprd.8b00095 |
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