Steps towards numerical verification of the terahertz in-line measurement of tablet mixing by means of discrete element modelling
Accepted version
Peer-reviewed
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Abstract
In recent years terahertz in-line sensing has been used to monitor the film coating thickness of individual pharmaceutical tablets during the coating process. In the previous work, the in-line measurements were verified against off-line measurements of samples from the same population. Here we report on our recent progress to further verify the validity of the terahertz in-line measurement modality using discrete element modelling for an artificial lab-scale tablet mixing process inside a tablet pan coater. By coupling discrete modelling with a ray-tracing method it is then possible to estimate the cumulative measurements taken, which in turn can guide towards the fine-tuning of the selection criteria as part of measurement analysis.
Description
Keywords
pharmaceuticals, coatings, pharmaceutical industry, ray tracing, mixing, discrete element method, numerical verification, tablet mixing, discrete element modelling, terahertz in-line sensing, film coating thickness, individual pharmaceutical tablets, measurement analysis, cumulative measurements, discrete modelling, tablet pan coater, artificial lab-scale tablet, terahertz in-line measurement modality, off-line measurements, in-line measurements, coating process
Journal Title
IET Microwaves, Antennas and Propagation
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Journal ISSN
1751-8725
1751-8733
1751-8733
Volume Title
12
Publisher
Institution of Engineering and Technology (IET)
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Sponsorship
Engineering and Physical Sciences Research Council (EP/L019922/1)
EPSRC Research Grants EP/L019787/1, EP/L019922/1.