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In vivo coupling of tau pathology and cortical thinning in Alzheimer's disease.

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cam.issuedOnline2018-09-17
dc.contributor.authorMak, Elijah
dc.contributor.authorBethlehem, Richard AI
dc.contributor.authorRomero-Garcia, Rafael
dc.contributor.authorCervenka, Simon
dc.contributor.authorRittman, Timothy
dc.contributor.authorGabel, Silvy
dc.contributor.authorSurendranathan, Ajenthan
dc.contributor.authorBevan-Jones, Richard W
dc.contributor.authorPassamonti, Luca
dc.contributor.authorVázquez Rodríguez, Patricia
dc.contributor.authorSu, Li
dc.contributor.authorArnold, Robert
dc.contributor.authorWilliams, Guy B
dc.contributor.authorHong, Young T
dc.contributor.authorFryer, Tim D
dc.contributor.authorAigbirhio, Franklin I
dc.contributor.authorRowe, James B
dc.contributor.authorO'Brien, John T
dc.contributor.orcidMak, Elijah [0000-0002-6437-8024]
dc.contributor.orcidBethlehem, Richard [0000-0002-0714-0685]
dc.contributor.orcidRittman, Timothy [0000-0003-1063-6937]
dc.contributor.orcidPassamonti, Luca [0000-0002-7937-0615]
dc.contributor.orcidWilliams, Guy [0000-0001-5223-6654]
dc.contributor.orcidAigbirhio, Franklin [0000-0001-9453-5257]
dc.contributor.orcidRowe, James [0000-0001-7216-8679]
dc.contributor.orcidO'Brien, John [0000-0002-0837-5080]
dc.date.accessioned2018-10-03T04:46:25Z
dc.date.available2018-10-03T04:46:25Z
dc.date.issued2018
dc.description.abstractINTRODUCTION: The deposition of neurofibrillary tangles in neurodegenerative disorders is associated with neuronal loss on autopsy; however, their in vivo associations with atrophy across the continuum of Alzheimer's disease (AD) remain unclear. METHODS: We estimated cortical thickness, tau ([18F]-AV-1451), and amyloid β (Aβ) status ([11C]-PiB) in 47 subjects who were stratified into Aβ- (14 healthy controls and six mild cognitive impairment-Aβ-) and Aβ+ (14 mild cognitive impairment-Aβ+ and 13 AD) groups. RESULTS: Compared with the Aβ- group, tau was increased in widespread regions whereas cortical thinning was restricted to the temporal cortices. Increased tau binding was associated with cortical thinning in each Aβ group. Locally, regional tau was associated with temporoparietal atrophy. DISCUSSION: These findings position tau as a promising therapeutic target. Further studies are needed to elucidate the casual relationships between tau pathology and trajectories of atrophy in AD.
dc.description.sponsorshipCambridge NIHR Biomedical Research Centre; Wellcome Turst, MRC, ARUK
dc.format.mediumElectronic-eCollection
dc.identifier.doi10.17863/CAM.30489
dc.identifier.eissn2352-8729
dc.identifier.issn2352-8729
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/283128
dc.languageeng
dc.language.isoeng
dc.publisherWiley
dc.publisher.urlhttp://dx.doi.org/10.1016/j.dadm.2018.08.005
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAlzheimer's disease
dc.subjectAmyloid
dc.subjectAtrophy
dc.subjectCortical thickness
dc.subjectMRI
dc.subjectPositron emission tomography
dc.subjectTau
dc.titleIn vivo coupling of tau pathology and cortical thinning in Alzheimer's disease.
dc.typeArticle
dcterms.dateAccepted2018-08-11
prism.endingPage687
prism.publicationDate2018
prism.publicationNameAlzheimers Dement (Amst)
prism.startingPage678
prism.volume10
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (unknown)
pubs.funder-project-idNational Institute for Health Research (NIHR) (via Cambridgeshire and Peterborough NHS Foundation Trust (CPFT) (DTC-RP-PG-0311-12001)
pubs.funder-project-idWellcome Trust (103838/Z/14/Z)
pubs.funder-project-idMedical Research Council (MR/K02308X/1)
pubs.funder-project-idMedical Research Council (G1100464)
pubs.funder-project-idMedical Research Council (MR/M009041/1)
pubs.funder-project-idMedical Research Council (MC_U105597119)
pubs.funder-project-idMedical Research Council (MR/M024873/1)
pubs.funder-project-idMedical Research Council (MC_UU_00005/12)
pubs.funder-project-idMedical Research Council (G1100464/1)
rioxxterms.licenseref.startdate2018-01
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1016/j.dadm.2018.08.005

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