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Exercise induces new cardiomyocyte generation in the adult mammalian heart.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Lerchenmüller, Carolin  ORCID logo  https://orcid.org/0000-0002-5620-0285
Wu, Ting-Di 
Guillermier, Christelle 
Rabolli, Charles P 

Abstract

Loss of cardiomyocytes is a major cause of heart failure, and while the adult heart has a limited capacity for cardiomyogenesis, little is known about what regulates this ability or whether it can be effectively harnessed. Here we show that 8 weeks of running exercise increase birth of new cardiomyocytes in adult mice (~4.6-fold). New cardiomyocytes are identified based on incorporation of 15N-thymidine by multi-isotope imaging mass spectrometry (MIMS) and on being mononucleate/diploid. Furthermore, we demonstrate that exercise after myocardial infarction induces a robust cardiomyogenic response in an extended border zone of the infarcted area. Inhibition of miR-222, a microRNA increased by exercise in both animal models and humans, completely blocks the cardiomyogenic exercise response. These findings demonstrate that cardiomyogenesis can be activated by exercise in the normal and injured adult mouse heart and suggest that stimulation of endogenous cardiomyocyte generation could contribute to the benefits of exercise.

Description

Keywords

Animals, Cell Proliferation, Cells, Cultured, Disease Models, Animal, Echocardiography, Heart, Humans, Male, Mice, Mice, Inbred C57BL, MicroRNAs, Myocardial Infarction, Myocardium, Myocytes, Cardiac, Physical Conditioning, Animal, Primary Cell Culture, Rats, Regeneration

Journal Title

Nat Commun

Conference Name

Journal ISSN

2041-1723
2041-1723

Volume Title

9

Publisher

Springer Science and Business Media LLC