Repository logo
 

Free Fatty Acid Receptors in Enteroendocrine Cells.

Accepted version
Peer-reviewed

Change log

Authors

Lu, Van B 
Gribble, Fiona M 

Abstract

Free fatty acid receptors (FFAs) are highly enriched in enteroendocrine cells providing pathways to link dietary fats and microbially generated short-chain fatty acids (SCFAs) to the secretion of a variety of gut hormones. FFA1 and FFA4 are receptors for long-chain fatty acids that have been linked to the elevation of plasma gut hormones after fat ingestion. FFA2 and FFA3 are receptors for SCFA, which are generated at high concentrations by microbial fermentation of dietary fiber and have also been implicated in enhancement of gut hormone secretion. FFAs are candidate drug targets for increasing the secretion of intestinal hormones such as glucagon-like peptide-1 and peptide YY as potential new treatments for type 2 diabetes and obesity. This review will examine aspects of intestinal physiology and pharmacology related to the function of FFAs in enteroendocrine cells.

Description

Keywords

Animals, Enteroendocrine Cells, Glucagon-Like Peptide 1, Humans, Peptide YY, Receptors, G-Protein-Coupled

Journal Title

Endocrinology

Conference Name

Journal ISSN

0013-7227
1945-7170

Volume Title

159

Publisher

The Endocrine Society
Sponsorship
Medical Research Council (MC_UU_12012/3)
Wellcome Trust (106262/Z/14/Z)
Medical Research Council (MC_UU_12012/1)
Medical Research Council (MC_UU_12012/5)
MRC (MC_UU_00014/3)
MRC (MC_UU_00014/5)
Medical Research Council (MC_PC_12012)