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Synthesis of High-Molecular-Weight and Strength Polyisobutylene-Based Polyurethane and Its Use for the Development of a Synthetic Heart Valve.

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cam.depositDate2022-05-12
cam.issuedOnline2022-10-25
cam.orpheus.counter48
cam.orpheus.successFri Sep 01 22:00:17 BST 2023 - Embargo updated*
dc.contributor.authorDeodhar, Tejal
dc.contributor.authorNugay, Nihan
dc.contributor.authorNugay, Turgut
dc.contributor.authorPatel, Ruhi
dc.contributor.authorMoggridge, Geoff
dc.contributor.authorKennedy, Joseph Paul
dc.contributor.orcidNugay, Turgut [0000-0002-2487-9932]
dc.date.accessioned2022-05-16T23:30:14Z
dc.date.available2022-05-16T23:30:14Z
dc.date.issued2023-01
dc.date.updated2022-05-12T14:10:01Z
dc.description.abstractUnder optimized synthesis conditions, for the first time, polyisobutylene-based polyurethane (PIB-PU) is prepared with 70% PIB soft segment (i.e., a bioinert and calcification-resistant PU) with Mn > 100 000 Da, 32 MPa ultimate strength, and 630% elongation. The key parameters for this achievement are a) the precise stoichiometry of the polyurethane forming reaction, specifically the use of highly purified di-isocyanate (4,4'-methylene-bis (phenyl isocyanate), MDI), and b) the increased solid content of the synthesis solution to the limit beyond which increased viscosity prevents stirring. The shape of the stress-strain trace of PIB-PU indicates a two-step failure starting with a reversible elastic (Hookean) region up to ≈50% yield, followed by a slower linearly increasing high-modulus-deformation region suggesting the strengthening of PIB soft segments by entanglement/catenation, and the hard segments by progressively ordering urethane domains. This PIB-PU is a candidate for a fully synthetic bioprosthetic heart valve since preliminary studies show that PIB-PU has impressive fatigue life.
dc.description.sponsorshipArmstrong Trust and Vice Chancellor's Scholarship
dc.identifier.doi10.17863/CAM.84620
dc.identifier.eissn1521-3927
dc.identifier.issn1022-1336
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/337202
dc.language.isoeng
dc.publisherWiley
dc.publisher.departmentDepartment of Chemical Engineering And Biotechnology
dc.publisher.urlhttp://dx.doi.org/10.1002/marc.202200147
dc.rightsAll Rights Reserved
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserved
dc.subjectfatigue life
dc.subjectfully synthetic bioprosthetic heart valves
dc.subjectmechanical properties
dc.subjectpolyisobutylene-based polyurethane
dc.subjectPolyurethanes
dc.subjectPolymers
dc.subjectPolyenes
dc.subjectHeart Valves
dc.titleSynthesis of High-Molecular-Weight and Strength Polyisobutylene-Based Polyurethane and Its Use for the Development of a Synthetic Heart Valve.
dc.typeArticle
dcterms.dateAccepted2022-05-12
prism.publicationNameMacromol Rapid Commun
pubs.licence-display-nameApollo Repository Deposit Licence Agreement
pubs.licence-identifierapollo-deposit-licence-2-1
rioxxterms.typeJournal Article/Review
rioxxterms.versionAM
rioxxterms.versionofrecord10.1002/marc.202200147

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