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Clinical application of autologous technetium-99m-labelled eosinophils to detect focal eosinophilic inflammation in the lung.



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Loutsios, Chrystalla 
Farahi, Neda 
Simmonds, Rosalind 
Cullum, Ian 
Gillett, Daniel 


The detection of focal eosinophilic inflammation by non-invasive means may aid the diagnosis and follow-up of a variety of pulmonary pathologies. All current methods of detection involve invasive sampling, which may be contraindicated or too high-risk to be performed safely. The use of injected autologous technetium-99m (Tc-99m)-labelled eosinophils coupled to single-photon emission computed tomography (SPECT) has been demonstrated to localise eosinophilic inflammation in the lungs of a patient with antineutrophil cytoplasmic antibody-positive vasculitis. Here, we report on the utility of this technique to detect active eosinophilic inflammation in a patient with focal lung inflammation where a biopsy was contraindicated.


This is the final version of the article. It first appeared from the BMJ Group via


Eosinophil Biology, Imaging/CT MRI etc, Pulmonary eosinophilia, Aged, Diagnosis, Differential, Eosinophils, Humans, Male, Pulmonary Eosinophilia, Radiopharmaceuticals, Technetium, Tomography, Emission-Computed, Single-Photon

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Medical Research Council (MR/J00345X/1)
Cambridge University Hospitals NHS Foundation Trust (CUH) (unknown)
The authors thank all the staff at the Department of Nuclear Medicine at Addenbrooke’s Hospital and the Wellcome Trust Clinical Research Facility, Cambridge; Cambridge Biomedical Research Centre Core Biochemistry Assay Laboratory; and the National Institute for Health Research, through the Comprehensive Clinical Research Network. This work was supported by Asthma-UK [08/11], the Medical Research Council [grant number MR/J00345X/1], the Wellcome Trust [grant number 098351/Z/12/Z], and Cambridge NIHR Biomedical Research Centre. Written informed consent was obtained in accordance with the Declaration of Helsinki. The study was approved by Cambridgeshire Research Ethics Committee (09/H0308/119) and the Administration of Radioactive Substances Advisory Committee of the United Kingdom (83/3130/25000).