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A genetic compensatory mechanism regulated by Jun and Mef2d modulates the expression of distinct class IIa Hdacs to ensure peripheral nerve myelination and repair

Published version
Peer-reviewed

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Type

Article

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Authors

Velasco-Aviles, Sergio 
Patel, Nikiben 
Casillas-Bajo, Angeles 
Frutos-Rincón, Laura 
Velasco-Serna, Enrique 

Abstract

The class IIa histone deacetylases (HDACs) have pivotal roles in the development of different tissues. Of this family, Schwann cells express Hdac4, 5 and 7 but not Hdac9. Here we show that a transcription factor regulated genetic compensatory mechanism within this family of proteins, blocks negative regulators of myelination ensuring peripheral nerve developmental myelination and remyelination after injury. Thus, when Hdac4 and 5 are knocked-out from Schwann cells in mice, a JUN-dependent mechanism induces the compensatory overexpression of Hdac7 permitting, although with a delay, the formation of the myelin sheath. When Hdac4,5 and 7 are simultaneously removed, the Myocyte-specific enhancer-factor d (MEF2D) binds to the promoter and induces the de novo expression of Hdac9, and although several melanocytic lineage genes are misexpressed and Remak bundle structure is disrupted, myelination proceeds after a long delay. Thus, our data unveil a finely tuned compensatory mechanism within the class IIa Hdac family, coordinated by distinct transcription factors, that guarantees the ability of Schwann cells to myelinate during development and remyelinate after nerve injury.

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Keywords

Schwann cells, cell biology, class II HDACs, gene compensation, mouse, myelin, nerve development, nerve regeneration, neuroscience, rat, Animals, Female, Gene Expression Regulation, Genes, jun, Histone Deacetylases, MEF2 Transcription Factors, Male, Mice, Peripheral Nerves, Remyelination, Schwann Cells

Journal Title

eLife

Conference Name

Journal ISSN

2050-084X
2050-084X

Volume Title

11

Publisher

eLife Sciences Publications Ltd
Sponsorship
Wellcome Trust (UNS38871)