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Contrast-Enhanced Multispectral Optoacoustic Tomography for Functional Assessment of the Gastrointestinal Tract.

Published version

Published version
Peer-reviewed

Repository DOI


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Authors

Paulus, Lars-Philip 
Buehler, Adrian 
Wagner, Alexandra L 
Raming, Roman 
Jüngert, Jörg 

Abstract

Real-time imaging and functional assessment of the intestinal tract and its transit pose a significant challenge to conventional clinical diagnostic methods. Multispectral optoacoustic tomography (MSOT), a molecular-sensitive imaging technology, offers the potential to visualize endogenous and exogenous chromophores in deep tissue. Herein, a novel approach using the orally administered clinical-approved fluorescent dye indocyanine green (ICG) for bedside, non-ionizing evaluation of gastrointestinal passage is presented. The authors are able to show the detectability and stability of ICG in phantom experiments. Furthermore, ten healthy subjects underwent MSOT imaging at multiple time points over eight hours after ingestion of a standardized meal with and without ICG. ICG signals can be visualized and quantified in different intestinal segments, while its excretion is confirmed by fluorescent imaging of stool samples. These findings indicate that contrast-enhanced MSOT (CE-MSOT) provides a translatable real-time imaging approach for functional assessment of the gastrointestinal tract.

Description

Funder: University Hospital of the Friedrich‐Alexander‐Universität (FAU) Erlangen‐Nürnberg

Keywords

indocyanine green, intestine, multispectral optoacoustic tomography, optoacoustics, photoacoustics, Humans, Tomography, X-Ray Computed, Indocyanine Green, Fluorescent Dyes, Phantoms, Imaging, Gastrointestinal Tract

Journal Title

Adv Sci (Weinh)

Conference Name

Journal ISSN

2198-3844
2198-3844

Volume Title

Publisher

Wiley
Sponsorship
Interdisciplinary Center for Clinical Research (J89)
CRUK (C9545/A29580)