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Living inside the box: environmental effects on mouse models of human disease.

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cam.issuedOnline2018-10
dc.contributor.authorSundberg, John P
dc.contributor.authorSchofield, Paul N
dc.contributor.orcidSundberg, John P [0000-0002-1523-5430]
dc.contributor.orcidSchofield, Paul N [0000-0002-5111-7263]
dc.date.accessioned2018-11-01T14:02:40Z
dc.date.available2018-11-01T14:02:40Z
dc.date.issued2018-10-01
dc.description.abstractThe impact of the laboratory environment on animal models of human disease, particularly the mouse, has recently come under intense scrutiny regarding both the reproducibility of such environments and their ability to accurately recapitulate elements of human environmental conditions. One common objection to the use of mice in highly controlled facilities is that humans live in much more diverse and stressful environments, which affects the expression and characteristics of disease phenotypes. In this Special Article, we review some of the known effects of the laboratory environment on mouse phenotypes and compare them with environmental effects on humans that modify phenotypes or, in some cases, have driven genetic adaptation. We conclude that the 'boxes' inhabited by mice and humans have much in common, but that, when attempting to tease out the effects of environment on phenotype, a controlled and, importantly, well-characterized environment is essential.
dc.description.sponsorshipNational Institutes of Health grants R01 AR049288, CA089713 and R21 AR063781. Warden and Fellows of Robinson College
dc.format.mediumElectronic
dc.identifier.doi10.17863/CAM.31872
dc.identifier.eissn1754-8411
dc.identifier.issn1754-8403
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/284497
dc.languageeng
dc.language.isoeng
dc.publisherThe Company of Biologists
dc.publisher.urlhttp://dx.doi.org/10.1242/dmm.035360
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectDiet
dc.subjectEnvironment
dc.subjectHuman
dc.subjectHusbandry
dc.subjectMouse models
dc.subjectStress
dc.subjectAnimals
dc.subjectCarcinogens
dc.subjectDiet
dc.subjectDisease Models, Animal
dc.subjectEnvironment
dc.subjectHumans
dc.subjectImmunity
dc.subjectLaboratories
dc.titleLiving inside the box: environmental effects on mouse models of human disease.
dc.typeArticle
dcterms.dateAccepted2018-07-12
prism.issueIdentifier10
prism.publicationDate2018
prism.publicationNameDis Model Mech
prism.volume11
rioxxterms.licenseref.startdate2018-10
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1242/dmm.035360

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