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Biopathology of childhood, adolescent and young adult non-Hodgkin lymphoma.

Accepted version
Peer-reviewed

Type

Article

Change log

Authors

Lim, Megan S 
Foley, Michelle 
Mussolin, Lara 
Siebert, Reiner 

Abstract

Mature non-Hodgkin lymphomas (NHL) in the childhood, adolescent and young adult (CAYA) population are rare and exhibit unique clinical, immunophenotypic and genetic characteristics. Application of large-scale unbiased genomic and proteomic technologies such as gene expression profiling and next generation sequencing (NGS) have led to enhanced understanding of the genetic basis for many lymphomas in adults. However, studies to investigate the pathogenetic events in CAYA population are relatively sparse. Enhanced understanding of the pathobiologic mechanisms involved in non-Hodgkin lymphomas in this unique population will allow for improved recognition of these rare lymphomas. Elucidation of the pathobiologic differences between CAYA and adult lymphomas will also lead to the design of more rational and much needed, less toxic therapies for this population. In this review, we summarize recent insights gained from the proceedings of the recent 7th International CAYA NHL Symposium held in New York City, New York October 20-23, 2022.

Description

Keywords

Adolescent and young adult, Childhood, Genetic, Non-Hodgkin lymphoma, Pathobiology, Humans, Adolescent, Young Adult, Proteomics, Lymphoma, Non-Hodgkin, Gene Expression Profiling, Genomics

Journal Title

Best Pract Res Clin Haematol

Conference Name

Journal ISSN

1521-6926
1532-1924

Volume Title

Publisher

Elsevier BV