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Role of lipid microdomains in TLR-mediated signalling.

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Ruysschaert, Jean-Marie 
Lonez, Caroline 


Over the last twenty years, evidence has been provided that the plasma membrane is partitioned with microdomains, laterally mobile in the bilayer, providing the necessary microenvironment to specific membrane proteins for signalling pathways to be initiated. We discuss here the importance of such microdomains for Toll-like receptors (TLR) localization and function. First, lipid microdomains favour recruitment and clustering of the TLR machinery partners, i.e. receptors and co-receptors previously identified to be required for ligand recognition and signal transmission. Further, the presence of the so-called Cholesterol Recognition Amino-Acid Consensus (CRAC) sequences in the intracellular juxtamembrane domain of several Toll-like receptors suggests a direct role of cholesterol in the activation process. This article is part of a Special Issue entitled: Lipid-protein interactions.


This is the accepted manuscript. The final version is available at


CRAC, Cholesterol, Lipid microdomains, Raft, Toll-like receptors, Amino Acid Sequence, Cholesterol, Humans, Membrane Lipids, Membrane Microdomains, Models, Molecular, Molecular Sequence Data, Protein Binding, Signal Transduction, Toll-Like Receptors

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Biochim Biophys Acta

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Elsevier BV
C.L. is an IEF Marie Curie Action Research Fellow (TLR4-CAT PIEF-GA-2012-326481).