Repository logo
 

An overview of the key routes to the best selling 5-membered ring heterocyclic pharmaceuticals.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Baumann, Marcus 
Baxendale, Ian R 
Ley, Steven V 
Nikbin, Nikzad 

Abstract

This review presents a comprehensive overview on selected synthetic routes towards commercial drug compounds as published in both journal and patent literature. Owing to the vast number of potential structures, we have concentrated only on those drugs containing five-membered heterocycles and focused principally on the assembly of the heterocyclic core. In order to target the most representative chemical entities the examples discussed have been selected from the top 200 best selling drugs of recent years.

Description

Keywords

five-membered rings, heterocycles, medicinal chemistry, pharmaceuticals, synthesis

Journal Title

Beilstein J Org Chem

Conference Name

Journal ISSN

1860-5397
1860-5397

Volume Title

7

Publisher

Beilstein Institut
Sponsorship
Engineering and Physical Sciences Research Council (EP/F069685/1)