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Heterogeneous Expression of Proangiogenic and Coagulation Proteins in Gliomas of Different Histopathological Grade.

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Wojtukiewicz, Marek Z 
Mysliwiec, Marta 
Matuszewska, Elwira 
Sulkowski, Stanislaw 
Zimnoch, Lech 


Brain gliomas are characterized by remarkably intense invasive growth and the ability to create new blood vessels. Angiogenesis is a key process in the progression of these tumors. Coagulation and fibrinolysis factors play a role in promoting angiogenesis. The aim of the study was to evaluate the expression of proangiogenic proteins (VEGF and bFGF) and hemostatic proteins (TF, fibrinogen, fibrin, D-dimers) associated with neoplastic cells and vascular endothelial cells in brain gliomas of various degrees of malignancy. Immunohistochemical tests were performed using the ABC method with the use of mono- and polyclonal antibodies. The obtained results indicated that both neoplastic cells and vascular endothelial cells in gliomas of various degrees of malignancy are characterized by heterogeneous expression of proteins of the hemostatic system and angiogenesis markers. The strongest expression of proangiogenic factors and procoagulant factors was demonstrated in gliomas of higher-grade malignancy.



D-dimers, VEGF, angiogenesis, bFGF, blood coagulation, fibrin, glial tumors 3, tissue factor, Angiogenic Proteins, Blood Coagulation Factors, Brain Neoplasms, Glioma, Humans, Neoplasm Grading, Neovascularization, Pathologic

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Pathol Oncol Res

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Frontiers Media SA