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Imaging Carotid Plaque Inflammation Using Positron Emission Tomography: Emerging Role in Clinical Stroke Care, Research Applications, and Future Directions.

Published version

Published version
Peer-reviewed

Repository DOI


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Authors

Evans, Nicholas R 
Gorey, Sarah 
Rudd, James HF 

Abstract

Atherosclerosis is a chronic systemic inflammatory condition of the vasculature and a leading cause of stroke. Luminal stenosis severity is an important factor in determining vascular risk. Conventional imaging modalities, such as angiography or duplex ultrasonography, are used to quantify stenosis severity and inform clinical care but provide limited information on plaque biology. Inflammatory processes are central to atherosclerotic plaque progression and destabilization. 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a validated technique for quantifying plaque inflammation. In this review, we discuss the evolution of FDG-PET as an imaging modality to quantify plaque vulnerability, challenges in standardization of image acquisition and analysis, its potential application to routine clinical care after stroke, and the possible role it will play in future drug discovery.

Description

Peer reviewed: True

Keywords

carotid, inflammation, positron emission tomography, prognosis, recurrence, stroke, Animals, Plaque, Atherosclerotic, Constriction, Pathologic, Fluorodeoxyglucose F18, Positron-Emission Tomography, Stroke, Coleoptera, Inflammation, Plaque, Amyloid

Journal Title

Cells

Conference Name

Journal ISSN

2073-4409
2073-4409

Volume Title

12

Publisher

MDPI AG
Sponsorship
EPSRC (EP/T017961/1)
Engineering and Physical Sciences Research Council (EP/N014588/1)
British Heart Foundation (None)
Medical Research Council (1966157)
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