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Fcγ Receptors in Solid Organ Transplantation.

Published version
Peer-reviewed

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Authors

Castro-Dopico, Tomas 
Clatworthy, Menna R 

Abstract

In the current era, one of the major factors limiting graft survival is chronic antibody-mediated rejection (ABMR), whilst patient survival is impacted by the effects of immunosuppression on susceptibility to infection, malignancy and atherosclerosis. IgG antibodies play a role in all of these processes, and many of their cellular effects are mediated by Fc gamma receptors (FcγRs). These surface receptors are expressed by most immune cells, including B cells, natural killer cells, dendritic cells and macrophages. Genetic variation in FCGR genes is likely to affect susceptibility to ABMR and to modulate the physiological functions of IgG. In this review, we discuss the potential role played by FcγRs in determining outcomes in solid organ transplantation, and how genetic polymorphisms in these receptors may contribute to variations in transplant outcome.

Description

Keywords

Antibodies, Antibody-mediated rejection, Fcγ receptors, IgG, Infection, Single nucleotide polymorphisms

Journal Title

Curr Transplant Rep

Conference Name

Journal ISSN

2196-3029
2196-3029

Volume Title

Publisher

Springer Science and Business Media LLC
Sponsorship
Medical Research Council (MR/N024907/1)
MRC is supported by the NIHR Cambridge BRC, the NIHR Blood and Transplant Research Unit (Cambridge) and by a Medical Research Council New Investigator Grant (MR/N024907/1).