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The Wnt signaling receptor Fzd9 is essential for Myc-driven tumorigenesis in pancreatic islets.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Zacarías-Fluck, Mariano F  ORCID logo  https://orcid.org/0000-0002-7171-4268
Jauset, Toni 
Martínez-Martín, Sandra  ORCID logo  https://orcid.org/0000-0003-4443-0697
Casacuberta-Serra, Sílvia  ORCID logo  https://orcid.org/0000-0002-2595-1115

Abstract

The huge cadre of genes regulated by Myc has obstructed the identification of critical effectors that are essential for Myc-driven tumorigenesis. Here, we describe how only the lack of the receptor Fzd9, previously identified as a Myc transcriptional target, impairs sustained tumor expansion and β-cell dedifferentiation in a mouse model of Myc-driven insulinoma, allows pancreatic islets to maintain their physiological structure and affects Myc-related global gene expression. Importantly, Wnt signaling inhibition in Fzd9-competent mice largely recapitulates the suppression of proliferation caused by Fzd9 deficiency upon Myc activation. Together, our results indicate that the Wnt signaling receptor Fzd9 is essential for Myc-induced tumorigenesis in pancreatic islets.

Description

Keywords

Adenoma, Islet Cell, Animals, Carcinogenesis, Cell Movement, Cell Proliferation, Female, Frizzled Receptors, Genes, myc, Islets of Langerhans, Male, Mice, Wnt Signaling Pathway, beta Catenin

Journal Title

Life Sci Alliance

Conference Name

Journal ISSN

2575-1077
2575-1077

Volume Title

4

Publisher

Life Science Alliance, LLC